Big Data’s Big Trap: Why Huge Datasets Can Be Precisely Wrong
A new PLOS Medicine guidance article warns that large biomedical datasets inflate statistical significance while leaving systematic bias intact, and ...
Tag: confounding
Early-Care Variables May Distort the Apparent Benefit of Neurosurgery-Capable Hospitals
A letter in Neurocritical Care argues that an odds ratio of 0.51 for traumatic brain injury mortality may reflect adjustment ...
Low-Dose Aspirin Linked to Lower Early Mortality in Sepsis Patients, but Causality Remains Uncertain
A retrospective MIMIC-IV study of 31,888 sepsis patients found documented low-dose aspirin use was associated with lower early mortality, though ...
Matching, weighting or stratification? Large-scale propensity score methods put to the test
A new methodological study compares matching, weighting and stratification strategies for large-scale propensity score adjustment across four national healthcare databases, ...
Neural Networks Join Propensity Scores to Sharpen Causal Effect Estimates in Observational Studies
A new method integrates artificial neural network-based propensity score and outcome regression information into a multi-index propensity score framework for ...
Noise emerges as the most consistent environmental link to cardiovascular emergencies in Germany
A nationwide German study of 3.78 million cardiovascular emergencies found that only environmental noise remained consistently associated with acute limb ...
New matching framework weaves polygenic risk into the search for disease causality
A new method called PRIMA incorporates polygenic risk scores into propensity score matching to help disentangle causal disease relationships from ...
High Uric Acid Linked to Slower Achilles Tendon Healing on MRI, But Experts Urge Caution
A new commentary cautions that an observed link between preoperative uric acid levels and MRI measures of early Achilles tendon ...
Systematic assessment finds confounding gap in multiple sclerosis trial emulations
A systematic assessment identified 160 potential confounders for target trial emulation in relapsing-remitting multiple sclerosis, revealing substantial gaps between clinical ...
Early Treatment Limits After Stroke May Signal Poor Prognosis, Not Cause Death
A post hoc analysis of the PRECIOUS trial across nine European countries finds that early treatment restrictions after acute stroke ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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