Granulosa Cell MYC Sustains Oocyte Quality Through Glycerophospholipid Metabolism in Mice
Deleting the Myc gene in mouse granulosa cells disrupts glycerophospholipid metabolism, damages oocyte spindles and causes female infertility.
Tag: conditional knockout
Polycomb Protein PCGF1 Steers Astrocyte Development by Guarding Notch Signals
Deleting the Polycomb protein PCGF1 in the mouse dorsal forebrain selectively blocks astrocyte production by lifting repression of N4bp1, a ...
Deleting Dopamine D2 Receptors from Cortical Interneurons Blunts Drug-Induced Hyperactivity in Mice
Mice lacking dopamine D2 receptors on medial ganglionic eminence-derived cortical interneurons showed significantly blunted locomotor responses to both MK-801 and ...
Scientists Switch Off a Key Mechanosensor in Tendon Cells and Map What Breaks
A conditional knockout study shows that deleting the mechanosensor YAP in stretched tendon cells disrupts a broad lipid-metabolism and immune-linked ...
Alzheimer’s Risk Gene BIN1 Acts as a Brake on Brain Inflammation
New research shows that the Alzheimer's risk gene BIN1 acts as a brake on microglial inflammation, and its loss exaggerates ...
Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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