Clinical Trials

James P. Allison, PhD, Carl H. June, MD and Siddhartha Mukherjee, MD Keynote April 29 SummitCredit: Alliance for Cancer Gene Therapy April 29 marks a pivotal moment in cancer research when the world's brightest minds come together to…

Credit: Lauren D. Quinn, University of Illinois URBANA, Ill. - Before humans can benefit from new drug therapies and nutritional additives, scientists test their safety and efficacy in animals, typically mice and rats. But, as much…

Credit: Sanford Burnham Prebys LA JOLLA, CALIF. - April 14, 2021 - Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two existing drug candidates--JAK inhibitors and Mepron--hold potential as…

Credit: NIAID A clinical trial testing the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus…

International study finds 4% of patients with metastatic renal cell carcinoma developed asymptomatic brain metastases, which correlated to poorer outcomesCredit: JNCCN PLYMOUTH MEETING, PA -- The April 2021 issue of JNCCN--Journal of…

Credit: Sergey Gnuskov/ NUST MISIS Young scientists from NUST MISIS have presented multilayer antibacterial coatings with a prolonged effect and a universal spectrum of action. The coating is based on modified titanium oxide and…

New patient-level data will facilitate more efficient clinical trial design TUCSON, Ariz., April 12, 2021 -- The Critical Path Institute's (C-Path) Critical Path for Alzheimer's Disease (CPAD) Consortium today announced that it is…

Researchers from the National Institutes of Health have identified and tested a drug combination that exploits a weakness in small cell lung cancer (SCLC), an aggressive, dangerous cancer. The scientists targeted a vulnerability in how the…

Credit: POSTECH Blood vessels deliver nutrients and oxygen to each organ in our body. They are difficult to completely restore to their original conditions once damaged by myocardial infarction or severe ischemic diseases. This is…

Scientists, medical researchers at Case Western Reserve, NYU Langone Health and University Hospitals using machine-learning to predict response to immunotherapyCredit: CWRU Medical researchers from Case Western Reserve University, New…

Study may improve clinical trials of therapeutics aimed at curing human immunodeficiency virus A new test that measures the quantity and quality of inactive HIV viruses in the genes of people living with HIV may eventually give researchers…

Breakthrough in the battle against brain cancerCredit: Tel Aviv University Groundbreaking research from Tel Aviv University may lead to a significant breakthrough in the battle against deadly brain cancer. To begin with, the…

For the first time, researchers led by SU2C "Dream Team" show how CD40 agonist drives an immune response to hard-to-penetrate tumors PHILADELPHIA--Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped…

Dana-Farber researchers find patients whose tumors have low aneuploidy levels often have better outcomes following treatment with immune checkpoint inhibitorsCredit: Dana-Farber Cancer Institute Patients with non-small cell lung…

New York, NY (April 10, 2021) - A personalized cancer vaccine developed with the help of a Mount Sinai computational platform raised no safety concerns and showed potential benefit in patients with different cancers, including lung and…

UCLA clinical trial shows bispecific CAR T cells targeting CD19/CD20 are safe and effective in patients with relapsed or refractory B-cell lymphoma LOS ANGELES -- Early results from a new, pioneering chimeric antigen receptor (CAR) T cell…

Credit: Frank Curran A new study using human genetics suggests researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal…

Early results show that a new combination drug therapy is safe and effective against advanced skin cancer in patients who were not able to have their tumors surgically removed. The drug combination is among the first, researchers say,…

Credit: University of Illinois College of Agricultural, Consumer and Environmental Sciences URBANA, Ill. - When scientists need to understand the effects of new infant formula ingredients on brain development, it's rarely possible…

SILVER SPRING, Md. - The U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research last week launched a Phase 2 clinical trial in Thailand to evaluate an interleukin-15 (IL-15) superagonist, ImmunityBio's…