Cellular Scissors: How the Deubiquitinase STAMBPL1 Shapes Health and Fuels Cancer
A new review details how the JAMM-family deubiquitinase STAMBPL1 maintains cellular homeostasis and, when overexpressed, drives tumor progression, metastasis, and ...
Tag: chemotherapy resistance
Ovarian Cancer Cells May Fuel Themselves With Potent Adrenal Androgens
New research shows that high-grade serous ovarian cancer cells can convert abundant adrenal 11-oxyandrogen precursors into the potent androgen 11-keto-testosterone, ...
Enzyme GDH1 Keeps Breast Cancer Persister Cells Alive During Chemotherapy
New research shows that the mitochondrial enzyme GDH1 sustains drug-tolerant persister cells in triple-negative breast cancer by coordinating glutamine metabolism, ...
Chemotherapy Rewrites Ovarian Cancer Drug Sensibility Without Touching the Genome
Patient-derived ovarian cancer organoids show that brief chemotherapy exposure reshapes sensitivity to second-line drugs such as cediranib and topotecan without ...
Longer Gaps Between Tarlatamab Doses Show Promise in Small Cell Lung Cancer
The randomized Phase 2 DeLLphi-309 study found that extended-interval tarlatamab dosing every three or four weeks produced efficacy, safety and ...
VALD-3 Triggers Pyroptosis in Triple-Negative Breast Cancer Through ROS/JNK/Bax Pathway
A synthetic compound derived from a family of molecules first described in the nineteenth century is emerging as a surprising ...
Pancreatic cancer organoids uncover genes driving chemotherapy resistance
Pancreatic ductal adenocarcinoma remains one of the most lethal malignancies in modern oncology, with five-year survival rates that have barely ...
Cannabinoids Suppress Chemotherapy- and Radiation-Induced Death in Glioblastoma Cells
Glioblastoma is among the most aggressive and difficult-to-treat brain cancers, and a new study is drawing attention to an unexpected ...
LIG1 Loss Reveals Targetable Weakness Against Chemotherapy-Resistant Triple-Negative Breast Cancer
In triple-negative breast cancer (TNBC) that carries TP53 mutations, loss of one copy of the DNA ligase I gene (LIG1) ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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