Study sends strong signal not to sequence immune checkpoint inhibitors in advanced kidney cancer
RESEARCH SUMMARY Study sends strong signal not to sequence immune checkpoint inhibitors in advanced kidney cancer Study Title: Efficacy and ...
Tag: checkpoint
Phase 3 SWOG Cancer Research Network trial, led by a City of Hope researcher, demonstrates one-year progression-free survival in 94% of patients with Stage 3 or 4 classic Hodgkin lymphoma who received a checkpoint inhibitor combined with chemotherapy
LOS ANGELES and PORTLAND, Ore. — A Phase 3 trial has demonstrated that patients with advanced stage (3 or 4) classic Hodgkin lymphoma who ...
Results of SWOG S1929 trial show patients with small-cell lung cancer with SLFN11 expression can benefit from PARP inhibitor added to immune checkpoint blockade
Among patients with extensive stage small-cell lung cancer (SCLC) that is positive for expression of the Schlafen-11 gene (SLFN11), those ...
Changes in RECIST tumor measures correlate linearly with survival in patients treated with checkpoint inhibitors
The Response Evaluation Criteria In Solid Tumors (RECIST), used in many clinical trials to evaluate changes in tumor burden over ...
Improving immune checkpoint inhibitors’ anti-tumor response and minimizing side effects
Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade (ICB) - a ...
Rice, Baylor developing ‘glyco-immune’ checkpoint inhibitor
HOUSTON – (May 19, 2023) – Researchers from Rice University and Baylor College of Medicine are hoping a first-of-its-kind “glyco-immune” ...
Immune Checkpoint Inhibitor Antitumor Response: Decoding Molecular Mechanisms
Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20–30% patients ...
New treatment regimen may decrease mortality in patients with cardiotoxicity from immune checkpoint inhibitors
Bottom Line: Among cancer patients who developed cardiotoxicity after treatment with immune checkpoint inhibitor (ICI) therapy, those treated with abatacept ...
Oncotarget | Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression
“One of the impediments to successful cancer therapy is the heterogeneity and cellular plasticity of the tumor and TME .” ...
Melanoma treatment: Potential target bypasses therapeutic resistance to immune checkpoint blockers
BIRMINGHAM, Ala. – Over the last decade, immune checkpoint blockers, or ICBs, have revolutionized treatment for various advanced cancers, including ...
Wistar scientists identify key biomarkers that reliably predict response to immune checkpoint inhibitor therapy for melanoma
PHILADELPHIA — (SEPTEMBER 19, 2022) — Immune checkpoint inhibitor (ICI) therapy is a type of treatment for melanoma, the deadliest ...
New checkpoint gene demonstrates ability to supercharge immune cells against cancer
MINNEAPOLIS/ST. PAUL (09/13/2022) — University of Minnesota researchers and their collaborators at the National Cancer Institute (NCI) investigated the role of a ...
Oncoscience | As expected, based on rapamycin-like p53-mediated gerosuppression, mTOR inhibition acts as a checkpoint in p53-mediated tumor suppression
“SASP is one of the mechanisms of tumor-promotion by senescent cells and is inhibited by both rapamycin and p53 .” ...
COVID-19 vaccines safe for patients treated for lung cancer with immune checkpoint inhibitors
(Denver—9 a.m. EDT--June 22, 2022)—Cancer patients have received priority status to receive COVID-19 vaccinations but there is limited data regarding ...
Illumination of immune checkpoint LAG3 ‘black box’ could yield new cancer and autoimmune therapies
PITTSBURGH, April 18, 2022 — Fighting cancer and chronic disease is tiring work for the immune system. When T cells ...
UCLA Jonsson Comprehensive Cancer Center scientists identify germline signature that predicts side effects from anti-PD1/PDL1 checkpoint therapy
Investigators from UCLA Jonsson Comprehensive Cancer Center have identified a germline biomarker signature that successfully predicts which patients will suffer ...
Immune checkpoint inhibitor atezolizumab as a potential game-changer in the treatment of early-stage NSCLC
With an estimated 2.2 million new cancer cases and 1.8 million deaths globally, lung cancer is the second most commonly ...
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Researchers discover genetic cause of megaesophagus in dogs
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Null results research now published by major behavioral medicine journal
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DNA facilitates escape from metastability
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A novel method for squeezing molecules together could significantly reduce chemical manufacturing waste and its negative environmental impacts
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Tiny video capsule shows promise as an alternative to endoscopy
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The problems with coal ash start smaller than anyone thought