Immune Checkpoint and Anti-EGFR Regimen Evaluated in Head and Neck Cancer
A retrospective study reports clinical activity and manageable safety for immune checkpoint inhibitors combined with anti-EGFR agents in recurrent or ...
Tag: Checkpoint
Common Medications May Alter Cancer Immunotherapy Outcomes
A narrative review published in Discover Medicine synthesizes preclinical and clinical evidence regarding the pharmacodynamic interactions between immune checkpoint inhibitors ...
Half of patients safely resumed cancer immunotherapy after heart concerns
A prospective single-centre cohort study found that half of patients with suspected cardiovascular immune-related adverse events were safely rechallenged with ...
Checkpoint Inhibitors Show Comparable Safety and Survival in Rheumatoid Arthritis
A matched cohort study found immune checkpoint inhibitors did not increase adverse events or worsen survival in cancer patients with ...
Adverse Event Profiles of Checkpoint Inhibitor Strategies in Metastatic Prostate Cancer
A systematic review and network meta-analysis of ten randomized trials evaluated the adverse event profiles of immune checkpoint inhibitor-based combination ...
ECP Safe for Steroid-Refractory Immune Side Effects
In a prospective, single-arm, non-randomized phase-Ib/II clinical trial published in Nature Communications, researchers evaluated the safety and activity of extracorporeal ...
Preclinical Study Identifies GALE as Checkpoint Restricting Vγ9Vδ2 T Cell Killing
A genome-wide CRISPR screen identified the metabolic enzyme GALE as a tumor-intrinsic checkpoint that limits Vγ9Vδ2 T cell-mediated tumor killing ...
When Cancer Immunotherapy Turns on the Heart
A new narrative review maps the rare but potentially fatal cardiovascular toxicities of immune checkpoint inhibitors, from fulminant myocarditis to ...
Low-Dose Cancer Immunotherapy Matches Standard Dose Efficacy
A comprehensive systematic review and meta-analysis has revealed that low-dose immune checkpoint inhibitors (ICIs) demonstrate comparable efficacy and safety profiles ...
Not All Immune Checkpoint Inhibitor Side Effects Are Equal for Survival
When a cancer patient develops a side effect during immunotherapy, oncologists often see it as a good sign — evidence ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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