Macrophage PD-L1 Loss Reduces CD80 Surface Expression
A new study in Frontiers in Oncology reveals that PD-L1 deletion or blockade in macrophages consistently reduces surface levels of ...
Tag: checkpoint inhibitors
Immunotherapy Safety Data May Not Apply to Borderline Resectable Lung Cancer
A narrative review argues that safety data from six phase 3 immunotherapy trials in resectable lung cancer may not transfer ...
Circulating tumor cells reveal immune escape tricks that may guide immunotherapy
A new review maps how circulating tumor cells survive immune attack in the bloodstream and outlines what evidence is still ...
Epigenetic Aging Inside Tumors May Shape Immunotherapy Response Beyond Chronological Age
A new review synthesizes evidence that DNA methylation, chromatin and non-coding RNA changes reshape immune and stromal cells in the ...
Aptamers Emerge as Programmable Building Blocks for Precision Cancer Immunotherapy
A new review maps how engineered DNA and RNA aptamers could enable targeted delivery and tumor microenvironment remodeling in precision ...
Checkpoint inhibitors improve survival in pMMR metastatic colorectal cancer meta-analysis
A meta-analysis of six randomized trials found that adding PD-1/PD-L1 inhibitors to chemotherapy was associated with longer progression-free and overall ...
Five Years Without Recurrence: Short-Course Immunotherapy Reshapes dMMR Colon Cancer Care
Long-term results from the phase 2 NICHE-2 trial show that none of 111 patients with dMMR colon cancer treated with ...
Immune Evasion in Metastatic Colorectal Cancer May Start Outside the Tumor Cell, Study Finds
An international research team reports that the sphingosine-1-phosphate signaling long thought to operate inside colorectal cancer cells instead builds an ...
A Shrinking Thymus May Blunt Cancer Immunity in Middle-Aged Men
New research in Nature Aging shows that accelerated loss of naive CD8+ T cells in middle-aged male mice shrinks lymph ...
Gut Microbe Transplants May Reverse Immunotherapy Resistance in Liver Cancer
A phase II pilot trial found that a single fecal microbiota transplantation combined with atezolizumab and bevacizumab was safe and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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