Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy
St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...
Tag: checkpoint blockade
Immune-cell switch flips the metabolic war between tumors and T cells in immunotherapy-resistant cancers
A new study shows that activating the lipid sensor PPARĪ“ in immune cells rather than cancer cells flips the metabolic ...
Immune Cell Engagers Evolve From Simple Bridges to Smart Biomaterial Platforms
A new review charts how immune cell engagers, from bispecific antibodies and aptamers to surface-engineered cells and nanoparticles, are being ...
Lab-Grown Brain Tumors Put Patient Immune Systems to the Test
A new review argues that patient-derived glioblastoma organoids could finally provide a realistic platform for testing immunotherapies, including oncolytic herpes ...
Gut Microbes Prime Regulatory B Cells That Shape Cancer Immunotherapy Outcomes
A new review explains how gut microbes program immunosuppressive regulatory B cells through cytokine and metabolite signals, with major implications ...
From Bench to Bedside: New Tools Push Veterinary Oral Cancer Toward Targeted Therapy
New spatial transcriptomics, patient-derived models, and comparative clinical trials of trametinib and a STAT3 decoy are transforming the treatment of ...
Scientists Map How Tumours Push Immune Cells Into Exhaustion
A review in Experimental & Molecular Medicine examines how chronic antigen exposure and a hostile tumour microenvironment reprogram T cells ...
T Cells Can Wipe Out Tumors Without Ever Recognizing Them
New research shows that activating bystander T cells inside tumors triggers antigen-independent tumor killing through cytokines, nitric oxide and innate ...
Neutrophil Traps That Feed Tumors: DNA Webs Emerge as Drivers and Markers of Cancer Progression
A new review details how neutrophil extracellular traps drive tumor growth, metastasis and treatment resistance while emerging as both biomarkers ...
AI maps collagen highways and myeloid roadblocks that trap T cells in pancreatic cancer
A new computational platform reveals how collagen architecture and myeloid cells cooperate to trap therapeutic T cells in pancreatic tumors, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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