Tag: CD8-positive T cells

A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...

Researchers report that Ailanthus excelsa quassinoids delivered in chitosan nanoparticles suppress STAT3-driven PD-L1 transcription and restore T-cell antitumor activity in ...

New research shows that activated platelets bind CD8-positive T cells via P-selectin and PSGL-1, directly suppressing their tumor-killing activity and ...

Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...

Researchers report that the antibiotic clofoctol redistributes CD8-positive T cells from the bone marrow and enhances their tumor-killing activity, substantially ...

New research reveals that radiotherapy induces PD-1 expression on tumor-associated monocytes through an adenosine-driven signaling pathway, creating an immunosuppressive cell ...

New research shows the anti-HER2 antibody-drug conjugate disitamab vedotin kills breast cancer cells through ferroptosis, releasing danger signals that activate ...

A longitudinal study of gastric cancer patients links baseline gut bacterial signatures, including Senegalimassilia and Lactobacillus, to response to chemoimmunotherapy ...

New research shows that the stromal protein RAMP3 drives macrophage-mediated immune exclusion in breast cancer and undermines PD-1 blockade, suggesting ...

New research shows that circulating tumor cells shed migrasomes carrying tumor antigens that activate CD8-positive T cells through cross-presentation, restricting ...