Responsive nanoparticles deliver ARV-771 to tumor cells
A proof-of-concept nanoparticle system used hyaluronic acid for CD44-mediated tumor-cell targeting and glutathione-triggered disassembly to release ARV-771 and enable BRD4 ...
Tag: CD44
Hyaluronic Acid-Coated Lipid Nanoparticles Show Promise for Longer-Lasting Knee Osteoarthritis Injections
Irish researchers have developed hyaluronic acid-coated solid lipid nanoparticles carrying a dexamethasone prodrug that suppressed inflammatory signalling in patient-derived cartilage ...
SPP1 emerges as a master switch shaping the tumor immune landscape
A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...
Injectable Gel Turns Old Blood Pressure Drug Into Breast Cancer Ally Against Doxorubicin Resistance
Researchers have developed a thermoresponsive injectable gel that co-delivers doxorubicin with reserpine to block P-glycoprotein and CD44, overcoming multidrug resistance ...
Gold Nanorods and Laser Light Strike at Cancer Stem Cells in Cats With Breast Tumors
A clinical trial in ten cats with spontaneous mammary carcinoma shows that gold nanorod-mediated plasmonic photothermal therapy significantly reduced circulating ...
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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