A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
Tag: CD19
CAR T-Cell Therapy Shows Durable Survival Gains in Aggressive Brain Lymphoma, Pooled Analysis Finds
A systematic review and meta-analysis of 23 studies and 547 patients finds that CD19-directed CAR T-cell therapy delivers encouraging one-year ...
Enhanced CAR T-Cell Therapy Shows Promise in Trial for B-Cell Blood Cancers
A phase I trial at Ohio State found that CAR T cells engineered to target three B-cell proteins and boosted ...
Donor-Derived CD19 CAR-T Cells Deliver Lasting Remissions in Leukemia Patients After Transplant Failure
A Chinese clinical study reports that donor-derived anti-CD19 CAR-T cells achieved complete remissions in 13 of 14 patients whose B-cell ...
Grid-Shaped Radiation Beats Conventional Beams in Boosting CAR T Therapy for Brain Lymphoma
A rat study shows that spatially fractionated minibeam radiation, unlike conventional radiotherapy, preserves the efficacy of CD19-directed CAR T cells ...
Lipid Nanoparticle CAR Engineering Reveals Synergy Between T Cells and Macrophages Against Leukemia
A new study shows that lipid nanoparticle-delivered CAR mRNA engineers both human T cells and macrophages against CD19-positive leukemia cells, ...
Silencing NOTCH1 Makes Leukemia Cells Vulnerable to CD19 CAR-T Attack
New research shows that blocking the NOTCH1 signaling pathway prevents leukemia cells from degrading the CD19 antigen, making them far ...
Tetraspanin Protein Supercharges CAR-T Cells by Amplifying IL-2 Signaling
Researchers report that the membrane protein TSPAN32 enhances CAR-T cell potency by assembling the IL-2 receptor complex and amplifying intracellular ...
Ibrutinib Triggers Matriptase to Preserve CD19 and Block Antigen Escape in B-Cell Malignancy
New research shows that the BTK inhibitor ibrutinib activates the protease matriptase in malignant B cells, preserving surface CD19 and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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