Fungal cell wall machine exposed: chitin synthase channel offers new antifungal target
Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a ...
Tag: Candida albicans
Engineering Microbes to Fight Disease, Plastics and Pollution
A new Microbial Biotechnology editorial shows how engineered microbes and enzymes are being deployed against fungal disease, diabetes, plastic waste ...
Nanofiber Mats Turn Amphotericin B Into a Safer, Sustained Topical Antifungal
Researchers have engineered electrospun poly(vinyl alcohol) nanofiber mats that deliver amphotericin B in a sustained, biocompatible manner with strong antifungal ...
Black Pepper and Stiff Juniper Oils Show Promise in New Multifunctional Wound Dressings
Researchers have identified black pepper and stiff juniper essential oils as powerful antimicrobial, antibiofilm, and antioxidant agents that can be ...
Two Soil Bacteria Compounds Strike Candida at Two Vulnerable Points at Once
Researchers report that two compounds from the soil bacterium Streptomyces chrestomyceticus ADP4 inhibit both the CYP51 ergosterol enzyme and exo-beta-1,3-glucanase ...
Green Silver-Zeolite Coating Turns Stainless Steel Implants Into Smart Drug-Releasing Antifungal Shields
Scientists have grown a green, silver-loaded ZSM-5 zeolite coating directly onto stainless steel implants that resists corrosion, fights Candida biofilms ...
Shorter Antifungal Courses May Not Raise Death Risk in ICU Patients With Candidemia
A multicenter French target trial emulation found that short-course antifungal therapy was not significantly associated with increased 90-day mortality in ...
Alcoholism Drug Disulfiram Restores Fluconazole Power Against Resistant Candida
Egyptian researchers found that the alcohol-aversion drug disulfiram synergizes with fluconazole, downregulates the Cdr1 efflux pump, and inhibits biofilm formation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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