Cancer’s Hidden Proteome: Thousands of Dark Proteins Emerge as Drug Targets
A landmark Perspective in Nature Reviews Cancer argues that the cancer dark proteome — thousands of uncharacterized proteins from non-canonical ...
Tag: cancer
Cancer cells recruit RNA editors and tRNA modifiers to survive immune attack
A genome-wide screen reveals that the RNA-editing enzyme ADAR1 and the tRNA methyltransferase FTSJ1 actively drive tryptophan-to-phenylalanine mistranslation in cancer ...
Brain-Penetrating Acridine Drug JP-1302 Cripples Cancer Cells by Shutting Down Ribosome Factory
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
Precision Nutrition: Tailoring Diet to Cancer Treatment Could Redefine Precision Medicine
A new narrative review argues that individualized dietary interventions, grounded in tumor metabolism and the gut microbiome, should be integrated ...
Massive phosphoproteome atlas maps kinase activity across 33 human cell lines
Researchers have built a phosphoproteome atlas covering more than 200,000 phosphorylation sites across 33 human cell lines, enabling faster phosphoproteomics ...
Zebrafish Help Scientists Solve a 30-Year Mystery of an Inflammation Signal That Both Alarms and Shields
MSK scientists identified the long-unknown enzyme behind the inflammatory signal 5-oxoETE and discovered that the pathway also protects healthy cells ...
Deaths Involving Both Alzheimer’s and Cancer Decline Slightly Yet Grow in Number Among Older Americans
A 25-year national analysis finds that age-adjusted U.S. death rates involving both Alzheimer's disease and cancer among adults aged 65 ...
New AI Tool miRDrug Maps the Shared Genes Behind MicroRNAs, Drugs and Resistance
Researchers have developed miRDrug, a machine-learning platform that integrates three biological databases to map the shared genes linking microRNAs, drugs ...
Cellular Antenna Turned Metabolic Command Center: How Primary Cilia Reshape Health and Disease
A new review redefines the primary cilium as a dynamic sensory-metabolic hub whose disruption contributes to cardiovascular, reproductive, metabolic, cancer ...
The Hidden Cost of Cancer Care: When Treatment Steals Patients’ Time
A new scoping review of 30 studies synthesizes the emerging evidence on time toxicity in cancer care, showing how treatment ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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