Urea cycle metabolite fuels leukemia growth by switching on a purine-recycling enzyme
A new Nature Metabolism study shows that BCR–ABL-driven leukemia cells hijack the urea cycle intermediate argininosuccinate to activate the nucleotidase ...
Tag: cancer metabolism
Enzyme GDH1 Keeps Breast Cancer Persister Cells Alive During Chemotherapy
New research shows that the mitochondrial enzyme GDH1 sustains drug-tolerant persister cells in triple-negative breast cancer by coordinating glutamine metabolism, ...
Plant Arginine Mimic Canavanine Disrupts Cancer Cell Metabolism and Signals
New research shows that the plant-derived arginine analogue canavanine represses ASS1 in a c-Myc-independent manner and synergizes with arginine deprivation ...
Cancer Cells Rewire Their Fuel Supply When This Growth Signal Switches On
New research reveals that HGF/c-MET signaling reprograms glutamine metabolism in MET-amplified head and neck cancer cells through ERK-dependent induction of ...
Fructose Fuels Pancreatic Cancer: New Vulnerability Found in KRAS G12D Tumors
A new review highlights fructose metabolism as a druggable weakness in KRAS G12D pancreatic tumors and proposes sodium citrate as ...
Iron and Methionine Metabolism Drive Fat Browning in Cancer Cachexia
A new Nature Cancer study identifies an iron-regulated methionine oxidation pathway and the repair enzyme MSRA as drivers of adipose ...
Mitochondrial Citrate Transporter SLC25A1 Drives Skin Cancer Through Histone Acetylation
Researchers in China have shown that the mitochondrial citrate transporter SLC25A1 promotes cutaneous squamous cell carcinoma by boosting histone H3 ...
Ketogenic Diets and Brain Cancer: Hope Outpaces the Evidence, Review Finds
A comprehensive systematic review of 43 studies finds that ketogenic diets and methionine restriction can alter tumor metabolism in glioblastoma, ...
Too Much Cysteine Comes at a Cost: Surplus Amino Acid Triggers Deadly Iron Overload in Cells
A new Nature Metabolism study shows that excess free cysteine disrupts mitochondrial iron homeostasis and triggers a distinct iron-dependent cell ...
Hidden Mitochondrial Transporters May Expose New Vulnerabilities in Colorectal Cancer
A new review highlights how three mitochondrial metabolite transporters are deregulated in colorectal cancer and jointly shape tumor metabolism, epigenetic ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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