Three overlooked amino acid transporters emerge as promising anti-cancer targets
A new review highlights the System N amino acid transporters SLC38A3, SLC38A5 and SLC38A7 as emerging metabolic vulnerabilities in cancer, ...
Tag: cancer metabolism
Cancer Cells Burn Energy on Futile Transcription by Shifting Their Genetic Start Lines
New research shows that cancer cells universally deregulate transcription start site selection, wasting energy on futile upstream transcription while protecting ...
Cancer Cells Run on a Metabolic Hybrid Engine, and Surgeons May Soon Map It
A new review argues that cancer cells toggle between glycolysis and mitochondrial respiration in hybrid metabolic states, and that mapping ...
How Nutrient Availability Rewires Mitochondria and Cytoskeleton in 3D Lung Cancer Models
A new systems-level study in 3D lung adenocarcinoma models shows that nutrient availability drives tumour cells into two distinct mitochondrial ...
Blood Lipid Patterns Could Predict Which Breast Cancers Respond to Chemotherapy
A new study finds that dynamic changes in blood lipid levels during chemotherapy can predict with high accuracy which luminal ...
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...
Cholesterol Plummets in Oral Cancer Patients, Huge Meta-Analysis Finds
A new meta-analysis of 25 studies finds that oral cancer patients show significantly lower total cholesterol, triglycerides, HDL, LDL, and ...
Ovarian Cancer’s Hidden Weakness: An Arginine Gateway on the Cell Surface
A detailed map of proteins on the surface of high-grade serous ovarian cancer cells has revealed that these tumors depend ...
Starving Tumors on a Chip: Glucose and Oxygen Steer Cancer Growth
A microfluidic 3D tumor model reveals that glucose limits proliferation, oxygen shapes architecture, and glutamine is essential for lung cancer ...
Blood Metabolites Reveal a Prognostic Fingerprint for Cervical Cancer
A GC-MS metabolomics study of 55 cervical cancer patients has identified serum biomarkers linked to disease stage, treatment and prognosis, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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