Hidden Mitochondrial Transporters May Expose New Vulnerabilities in Colorectal Cancer
A new review highlights how three mitochondrial metabolite transporters are deregulated in colorectal cancer and jointly shape tumor metabolism, epigenetic ...
Tag: cancer metabolism
Mitochondrial Enzyme SUCLG2 Emerges as a Tumor Suppressor in Colorectal Cancer
Researchers found that the mitochondrial enzyme SUCLG2 suppresses colorectal cancer by lowering SAM levels to demethylate GADD45G and reactivate p53-mediated ...
Thyroid Cancer Protein Rewires Tumor Metabolism and Drives Drug Resistance
New research shows the protein ECT2 drives papillary thyroid carcinoma growth by suppressing lipoic acid metabolism, activating PI3K/AKT signaling and ...
Scientists Target the CD73-Adenosine Axis to Break Lung Cancer’s Immune Shield
A new review maps how the CD73-adenosine axis drives immune suppression in non-small cell lung cancer and how blocking it ...
Argininosuccinate Signal Fuels Carbon Replenishment in Leukaemia Cells
New research in Nature Metabolism shows that phosphorylated ASS1 in B cell acute lymphoblastic leukaemia produces argininosuccinate, which activates NT5C2 ...
PGAM1 Links Glycolysis and Autophagy to Control Growth and Stress Resilience
A familiar enzyme at the center of cellular energy production has been found to perform a second, unexpectedly powerful job: ...
Targeting POLG Weakens Breast Cancer Stemness by Disrupting Mitochondrial Function
A new study is drawing attention to a possible metabolic vulnerability in breast cancer stem cells: the mitochondrial DNA maintenance ...
Targeting Purine Metabolism Emerges as a Next-Generation Cancer Treatment Strategy
Cancer cells do not merely consume more nutrients than healthy cells; they redesign the systems that process those nutrients to ...
FOXK2 discoveries broaden understanding of cancer biology and clinical care
A comprehensive review published in Genes & Diseases is drawing renewed attention to FOXK2, a transcription factor that may help ...
AHCY–Adenosine Complex Boosts Fatty Acids, Cancer
In a groundbreaking study set to redefine our understanding of cancer metabolism and RNA modification, researchers have uncovered a novel ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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