Two BCL-2 Gene Variants Linked to Protein Levels and Aggressive Bladder Cancer
Brazilian researchers have found that a BCL-2 promoter variant influences protein expression in bladder tumors while a specific haplotype triples ...
Tag: Cancer Genetics
Hidden inherited cancer risks surface in routine tumor sequencing, oncologists warn
The practical framework outlined by Zhang and Madlensky arrives at a moment when the infrastructure of precision oncology is being ...
One DNA Test Could Transform How Doctors Classify Endometrial Cancer
A single next-generation sequencing panel covering 116 cancer-related genes matches the traditional multi-platform approach for classifying endometrial carcinoma, while catching ...
Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Hidden Genetic Threads Link Cancers Through Shared Regions and Pathways
A new PLOS Genetics study shows that shared genetic susceptibility across cancers is modest genome-wide but becomes structured and biologically ...
A Single DNA Letter Tweak Rewires a Cancer Gene’s Translation and Stress Response
A common inherited variant in the DDIT4 3′ UTR controls translation efficiency of the tumor-suppressing stress-response gene, reshaping mTOR signaling, ...
Massive Genetic Study Uncovers 18 DNA Regions Linked to Pancreatic Cancer Risk
A cross-population meta-analysis of over 1.4 million people identified 18 genetic loci for pancreatic cancer, including four new ones, along ...
Tiny DNA Insert in a Super-Enhancer Fine-Tunes Two Cancer Genes in Breast Tumors
A common germline insertion within a bifunctional super-enhancer dampens the expression of the cancer-promoting genes LINC00636 and CD47 in breast ...
CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Telomerase and β-Catenin Join Forces to Drive Aggressive Liver Cancer
A new study shows that TERT promoter mutations synergize with β-catenin activation to accelerate liver cancer development through the MAPK/ERK ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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