Network and cell study links carboplatin to four melanoma targets
Network analysis and B16F0 cell experiments linked carboplatin with CDKN1A, BRCA1, PTEN and AKT1 in melanoma, without establishing clinical benefit.
Tag: BRCA1
BRCA1 Carriers Respond Better to Breast Cancer Chemotherapy, Landmark Chinese Study Finds
A study of 1,009 Chinese breast cancer patients found that BRCA1 mutation carriers had far higher rates of complete tumor ...
Genetic Testing Reveals Hidden Gaps in Care for Women at High Breast Cancer Risk
A new survey of nearly 1,000 women with hereditary breast cancer susceptibility genes reveals that financial and emotional support services ...
Lactation Drug Cabergoline May Cut Postpartum Breast Cancer Risk, Study Finds
A widely used lactation-suppressing drug, cabergoline, was linked to a sharply lower postpartum breast cancer risk in women and halved ...
Personalized Navigation Boosts Hereditary Cancer Genetic Testing Among Relatives
A randomized trial at MD Anderson Cancer Center found that personalized navigation support raised BRCA genetic testing uptake among at-risk ...
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
BRCA Carriers Show Distinct Protein Signatures in Healthy Breast Tissue, Study Finds
A Mayo Clinic-led proteomic study of nearly 5,000 proteins in nonmalignant breast tissue reveals that cancer-free BRCA1/2 mutation carriers show ...
Aggressive Ovarian Cancer Found at 10 Weeks of Pregnancy Exposes Diagnostic Dilemmas
A case report in Oncoscience describes high-grade serous ovarian carcinoma diagnosed at ten weeks of gestation, illustrating the diagnostic and ...
Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Colombian Study Tracks Ten-Year Survival in Breast Cancer Patients Carrying Inherited Risk Variants
A retrospective cohort of 259 Colombian breast cancer patients with germline pathogenic variants found a ten-year overall survival of 75 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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