Plant Compounds Emerge as Potential Dual Blockers of Brain-Damaging Enzymes
A computational study identifies plant-derived compounds, notably coumarin, as promising dual inhibitors of the ROCK1 and ROCK2 enzymes that regulate ...
Tag: blood-brain barrier
Sick Kidneys, Misfiring Pituitary: How Chronic Kidney Disease Scrambles the Brain’s Hormone Command Center
A new review argues that chronic kidney disease may dysregulate pituitary hormones through uremic toxins, inflammation, disrupted FGF23-Klotho signaling, microRNAs, ...
Lower-Dose Bevacizumab Matches Higher Dose for Brain Radiation Necrosis, Study Finds
A multicenter study of 104 patients finds that lower-dose and higher-dose bevacizumab produce similar radiographic outcomes in brain radiation necrosis, ...
Scientists Discover Twelve New Autoantibody Signatures Linked to Parkinson’s Disease
A two-stage study of 340 participants in Singapore has identified twelve autoantibodies elevated in Parkinson's disease patients, linked to translation ...
Protein Therapy Aims to Restore Brain Function in Fragile X Syndrome
A UC Riverside team funded by FRAXA will test engineered proteins designed to cross the blood-brain barrier and normalize brain ...
Bioprinted Blood–Brain–Tumor Barrier Spheroids Put a ROS-Producing Ruthenium Drug to the Test Against Glioblastoma
Researchers built a 3D bioprinted blood–brain–tumor barrier spheroid that self-organizes into barrier and tumor layers and showed that a ROS-producing ...
Neutralizing Histones Shields the Stroke-Injured Brain from Pneumonia Damage
New research shows that antibody-mediated neutralization of extracellular histone proteins protects the ischemic brain from the neutrophil-driven damage caused by ...
Bacterial Toxin Challenge Gets a Timing Makeover in the Hunt for Brain-Saving Plant Compounds
A new review proposes a kinetics- and mechanism-informed framework for using lipopolysaccharide-induced neuroinflammation models to screen phytochemicals with greater rigour ...
First Multiomic Atlas Reveals How the Human Brain’s Protective Layers Build Their Immune Defenses
A paired single-nucleus RNA and chromatin atlas with spatial transcriptomics charts how the human meninges, their blood-brain barrier endothelium, yolk ...
Immune Webs of DNA May Drive Brain Bleeding After High-Sugar Stroke
New research shows that neutrophil extracellular traps driven by high blood sugar worsen bleeding complications after ischemic stroke, and that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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