Marine Compounds Offer New hope for Alzheimer’s Drug Design, Study Suggests
A new computational study in Heliyon used pharmacophore modeling of marine-derived compounds to design synthetic gamma-secretase modulators that outperformed a ...
Tag: blood-brain barrier
Brain vessel exosomes home to injury sites to rescue cerebral energy crisis
A new study reports that exosomes released by cerebral endothelial cells can home to traumatic brain injury sites and restore ...
Exercise Hormone Irisin Reveals a Complete Molecular Route From Muscle to Brain Protection in Alzheimer’s Disease
A new review in Biogerontology maps the complete molecular cascade by which the exercise hormone irisin travels from skeletal muscle ...
New Hydrophobic Tag Molecule Degrades DAPK1 and Cuts Tau Pathology in Alzheimer’s Mice
Scientists created CJ1, a hydrophobic tagging molecule that selectively destroys the DAPK1 kinase via the proteasome, reducing tau phosphorylation, neurofibrillary ...
Brain Gatekeeper Found to Ferry Serine That Builds Young Synapses
New research in iScience identifies the blood-brain barrier transporter SLC38A2 as a critical route for dietary L-serine entry into the ...
Nanomedicines Offer New Routes Past the Brain’s Defenses Against Drug-Resistant Tumours
A new review in Molecular Cancer details how five classes of nanomaterials could breach the blood–brain barrier and dismantle the ...
New Sequencing Methods Capture the Brain’s Hidden Vascular Cells
A newly published Nature Protocols paper details VINE-seq and MultiVINE-seq, streamlined workflows that isolate brain vessels and extract their nuclei ...
Obesity’s Toll on the Brain: How Midlife Weight Drives Cognitive Decline and Dementia Risk
A comprehensive review in Nature Reviews Neurology details how obesity damages the hypothalamus, hippocampus and cerebrovasculature to drive cognitive decline, ...
Arthritis Drug Diacerein Shows Surprising Power Against Deadly Brain Cancer
Researchers report that the osteoarthritis drug diacerein kills glioma cells by triggering caspase-3 and GSDME-mediated pyroptosis, revealing a new drug-repurposing ...
AI Scours 1.2 Million Natural Products to Find Fungal Compound That Starves Glioblastoma of Cholesterol
An AI-driven screening pipeline identified the fungal sterol 5,6-epoxyergosterol as a selective LXRβ agonist that exploits the cholesterol dependency of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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