Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
Tag: Biomarkers
Blood Protein Test Predicts Seven Years of Nerve Damage in Rare Genetic Disease
A seven-year Dutch study shows that a single baseline blood measurement of neurofilament light chain predicts the pace of spinal ...
Blood Test for Antioxidant Capacity May Predict Recovery From Bipolar Mania
A four-week follow-up study of 70 patients with bipolar mania found that changes in total antioxidant capacity significantly predicted symptomatic ...
New Biomarkers and AI Aim to Cut Unnecessary Prostate Biopsies Before the Needle
A new review in Medical Oncology details how liquid biomarkers, advanced imaging, and artificial intelligence are transforming pre-biopsy discrimination of ...
Clinical Risk Scores Cannot Stand In for Neurofilament Biomarkers in ALS Trials, Study Finds
A reanalysis of the MIROCALS trial shows that the TRICALS clinical risk score adds useful prognostic information in ALS but ...
Follicular Fluid Proteins Reveal Metabolic and Immune Clues in Ovarian Syndrome
Using 4D label-free proteomics, researchers identified 33 differentially expressed proteins in follicular fluid from patients with polyendocrine metabolic ovarian syndrome, ...
Blood Sample Trajectories Years Before Diagnosis Predict Osteoporosis Risk
Repeated pre-diagnostic blood donations from Danish donors reveal that longitudinal metabolite trajectories, particularly declining hippuric acid, predict osteoporosis one to ...
Landmark Trial Pinpoints Which HER2-Positive Breast Cancers Respond to Shorter, Gentler Chemotherapy
Secondary results from the ECOG-ACRIN CompassHER2-pCR trial identify clinical and molecular factors, including HER2DX genomic scores, that predict which stage ...
Immune Blood Markers Offer Rapid Roadmap to Identify Infection Cause and Severity
Researchers at Sun Yat-sen Memorial Hospital have developed a hierarchical diagnostic pathway using cytokines and routine inflammatory markers to rapidly ...
Fifteen-Year Study Reveals How Lipoprotein(a) Levels Shift Over a Lifetime
A 15-year Taiwanese cohort study of 17,363 adults shows lipoprotein(a) levels are largely stable over time, with statin initiation, diabetes, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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