Asthma biologics omalizumab and dupilumab both ease symptoms but move IgE in opposite directions
A retrospective real-world cohort of 72 adults with moderate-to-severe asthma found both omalizumab and dupilumab improved asthma control and lung ...
Tag: biologic therapy
Three Baseline Gene-Expression Endotypes Track With Healing in Ulcerative Colitis
An integrative reanalysis of 778 baseline mucosal transcriptomes from public ulcerative colitis cohorts identified three gene-expression endotypes that stratify healing ...
Single-Inhaler Triple Therapy and Biologics Reshape COPD Treatment, Review Finds
A narrative review synthesizes real-world evidence supporting single-inhaler triple therapy and the emergence of dupilumab, mepolizumab and the investigational anti-IL-33 ...
Ustekinumab trough levels associated with remission in 76 adults in single-center Crohn’s study
A cross-sectional study of 76 adults with Crohn’s disease at a Baghdad hospital found that higher ustekinumab trough concentrations were ...
Tocilizumab Rechallenge at Reduced Dose Still Triggers Fibrinogen Crash in Arthritis Patient
A case report shows tocilizumab-induced hypofibrinogenemia recurred in a rheumatoid arthritis patient even after the drug dose was substantially reduced.
Tildrakizumab Shows Sustained Real-World Benefit in Japanese Psoriasis Patients Over 52 Weeks
A 52-week Japanese observational study found that tildrakizumab sustained meaningful disease control in real-world psoriasis patients, with 60 percent achieving ...
Machine learning reveals four hidden lupus phenotypes among patients starting belimumab
An unsupervised machine-learning analysis of the Italian LIRE registry has identified four clinically distinct phenotypes among systemic lupus erythematosus patients ...
Trapped Hairs Inside Sinus Tracts May Explain Why a Severe Scalp Disease Resisted Biologics
A Japanese case report describes dissecting cellulitis of the scalp that resisted two biologic drugs, with surgery revealing hair shafts ...
Ustekinumab Works Best in Crohn’s Disease Patients New to Biologics, Real-World Study Finds
A retrospective study of 61 Crohn's disease patients in China found that ustekinumab delivers stronger inflammatory control and endoscopic healing ...
Rituximab’s Second Act: Rethinking B-Cell Depletion for Lupus Treatment
A new review maps where the off-label anti-CD20 antibody rituximab fits in the treatment of systemic lupus erythematosus, from refractory ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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