Same Drug, Different Cells: Why mTOR Inhibition in Plaques Defies Simple Rules
A new review argues that mTOR's effects in atherosclerotic plaques depend on cell state, plaque niche, signalling complex and drug ...
Tag: atherosclerosis
How Blood Flow Forces Shape Erections: The Biomechanics of Penile Endothelium
A new review argues that fluid shear stress acting on cavernous endothelial mechanosensors, from the glycocalyx to Piezo1 channels, is ...
DDIT4 protein worsens artery narrowing by disrupting smooth muscle cell metabolism
A Nature Communications study shows that the protein DDIT4 drives vascular smooth muscle cell switching and artery thickening in mice ...
Late-life blood pressure decline signals brain vessel damage in women
An autopsy study of 2,033 older adults links faster late-life systolic blood pressure decline to more severe brain arteriolosclerosis and ...
Experimental drug rejuvenates aged rat livers, halving amyloid beta and LDL
In aged rats, the experimental drug cinaciguat restored aging liver sieve cells, cutting blood amyloid beta in half and lowering ...
Chemical Tags on RNA May Steer the Course of Aortic Dissection
A new review details how the RNA modification m6A influences cell death, inflammation and risk factors in aortic dissection, pointing ...
Plaque Transcriptomics Point to BCAP31 as a Stress Buffer in Carotid Atherosclerosis
An integrated analysis of human carotid plaque transcriptomes and macrophage experiments suggests that elevated BCAP31 in atherosclerotic lesions may reflect ...
Review links macrophage mitochondrial imbalance to atherosclerosis progression
A 2026 review finds that experimental manipulation of macrophage mitochondrial quality control can change plaque development, but most supporting evidence ...
Framework Separates DNA-Sensing Claims by Cell Type and Disease Stage
A focused review finds that cGAS–STING and AIM2 claims in atherosclerosis depend on the DNA source, cellular lineage, disease stage ...
Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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