Urea cycle metabolite fuels leukemia growth by switching on a purine-recycling enzyme
A new Nature Metabolism study shows that BCR–ABL-driven leukemia cells hijack the urea cycle intermediate argininosuccinate to activate the nucleotidase ...
Tag: ASS1
Plant Arginine Mimic Canavanine Disrupts Cancer Cell Metabolism and Signals
New research shows that the plant-derived arginine analogue canavanine represses ASS1 in a c-Myc-independent manner and synergizes with arginine deprivation ...
Argininosuccinate Signal Fuels Carbon Replenishment in Leukaemia Cells
New research in Nature Metabolism shows that phosphorylated ASS1 in B cell acute lymphoblastic leukaemia produces argininosuccinate, which activates NT5C2 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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