Aspirin Linked to Lower Alzheimer’s Risk in New Integrative Study
A new integrative study identifies aspirin as a candidate for Alzheimer’s disease repurposing, linking early use to lower risk in ...
Tag: APOE ε4
Sleep Breathing Issues Linked to Brain Barrier Markers
A study of 409 participants found that sleep-disordered breathing is associated with elevated cerebrospinal fluid markers of blood-brain barrier dysfunction ...
Rare SORL1 variants shape a typical Alzheimer’s profile, with hints of faster decline in one genetic subgroup
A study of 1,546 patients with biomarker-confirmed symptomatic Alzheimer's disease found that 35 carriers of rare high-risk SORL1 variants showed ...
Hormone therapy linked to subtly rising depressive symptoms in older women
A longitudinal study of cognitively unimpaired older adults found that women using post-menopausal hormone therapy reported subtly greater increases in ...
Baseline Amyloid Levels Predict One-Year Clearance on Donanemab, Analysis Shows
A post hoc analysis of the TRAILBLAZER-ALZ 2 trial found that lower baseline amyloid, older age, fewer APOE ε4 alleles ...
Beta-brain-wave dips may link amyloid buildup to memory loss in early Alzheimer’s
A resting-state EEG study of amyloid-positive mild cognitive impairment finds that reduced beta-band activity indirectly links amyloid burden to memory ...
Diabetes Dementia Risk Hinges on APOE ε4 and Alpha-Klotho, Review Argues
A narrative review proposes that APOE ε4 amplifies diabetes-related cognitive decline across metabolic, vascular, and neurodegenerative layers, while α-Klotho may ...
Lecanemab shows favorable real-world safety in Korean registry study of 663 patients
A Korean registry study of 663 patients at 32 hospitals found lecanemab had favorable real-world safety, with ARIA in 16.1 ...
MRI study maps two sequences of brain barrier leaks and thinning in cognitive impairment
A SuStaIn analysis of DCE-MRI and structural MRI data from 216 participants identified atrophy-first and BBB-first subtypes with distinct cognitive ...
APOE ε4 Carriers Face Higher Heart Attack Risk, Large Genetic Review Finds
A new meta-analysis of 36 case-control studies links the APOE ε4 allele to increased heart attack risk, with the strongest ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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