Tau Takes Center Stage: New Review Maps the Phosphorylation Network Driving Alzheimer’s Disease
A new review in the Journal of Translational Medicine reframes tau phosphorylation as a dynamic hub within a multi-scale network ...
Tag: antisense oligonucleotides
Computers Take the Guesswork Out of Antisense Drug Design
A new review maps how computational tools, from RNA folding algorithms to molecular dynamics simulations, are transforming the design of ...
Antibody-DNA Hybrids Push Ultrasensitive Diagnostics and RNA Drugs Forward
A new review in LabMed Discovery surveys how antibody-oligonucleotide conjugates combine antibody targeting with nucleic acid programmability for ultrasensitive proteomics ...
RNA-Destroying Enzyme Regnase-1 Emerges as a Master Switch in Autoimmune Disease
A new review in Molecular Biology Reports argues that the RNA-degrading enzyme Regnase-1 and its family members act as cell-type-specific ...
Hidden RNA Switches Offer a New Way to Boost Genes in Rare Disease
Scientists have shown that removing hidden repressive elements from RNA messages with splice-switching antisense oligonucleotides can boost protein production from ...
Four Decades of Hunting the Misfolded Protein: How Prion Research Grew Into a Blueprint for Neurodegenerative Drug Design
A new review in Acta Neuropathologica chronicles four decades of Byron Caughey's pioneering work on prion disease inhibitors, from infrared ...
RModBlock antisense oligonucleotides enable universal, efficient inhibition of RNA modifications
Scientists have long wanted a way to switch off specific chemical marks on RNA at defined sites, to clarify how ...
Innovative Approach to Enhance the Effectiveness of RNA Therapies
A groundbreaking study spearheaded by researchers at the University of Basel offers a transformative insight into the intracellular dynamics that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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