A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
Tag: antigen escape
CAR-T Cell Therapy Faces Its Next Test: Solid Tumours, Safer Designs and Lower Costs
A comprehensive review maps the engineering, biomarker, manufacturing and economic innovations that will determine whether CAR-T cell therapy can move ...
Ibrutinib Triggers Matriptase to Preserve CD19 and Block Antigen Escape in B-Cell Malignancy
New research shows that the BTK inhibitor ibrutinib activates the protease matriptase in malignant B cells, preserving surface CD19 and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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