T-DM1 Shows Limited Activity After T-DXd in HER2-Positive Metastatic Breast Cancer
A single-center study of 21 patients found that trastuzumab emtansine produced no responses and a median progression-free survival of 2.20 ...
Tag: antibody-drug conjugates
Two breast cancer drugs match on progression control, but only one shows a survival benefit
An indirect comparison finds sacituzumab govitecan and datopotamab deruxtecan comparable in progression control, but only sacituzumab govitecan has direct randomized ...
Computational agent pinpoints ADAM17 as drug target in biliary tract cancer
An AI-driven target discovery framework ranked ADAM17 first for biliary tract cancer, and antibody-drug conjugates and CAR-T cells built against ...
Men live longer on enfortumab vedotin than women, retrospective analysis finds
A retrospective international analysis found male metastatic urothelial carcinoma patients survived longer on enfortumab vedotin than females, with higher NECTIN-4 ...
Antibody-Drug Conjugates Extend Survival in Triple-Negative Breast Cancer, Meta-Analysis Finds
A systematic review and meta-analysis of six studies covering 2,479 patients found that antibody-drug conjugates significantly improved progression-free and overall ...
VCU grant funds study of TROP2-targeted drugs in breast and pancreatic cancers
A five-year National Cancer Institute grant will fund laboratory research into response biomarkers and resistance mechanisms for TROP2-targeted antibody-drug conjugates ...
Virtual biotech deploys 37,000 AI agents across drug discovery
A Stanford-developed virtual biotech used 37,000 AI agents to analyze 50,000 trials, identify markers linked to drug success and design ...
Antibody–drug conjugates amplify cancer immunotherapy in selected solid tumors
A review of clinical and preclinical evidence finds that antibody–drug conjugates can improve outcomes with immune checkpoint inhibitors in several ...
mRNA-encoded antibodies show early clinical promise in cancer therapy
A Journal of Translational Medicine review outlines how mRNA-encoded antibodies, bispecific constructs, and transient CAR expression could overcome the manufacturing ...
Gastric protein CLDN18.2 emerges as candidate biomarker in mucinous colorectal cancer
A new review finds that the gastric tight-junction protein CLDN18.2, rare in conventional colorectal cancer, is enriched in mucinous colorectal ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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