Antibody–Drug Conjugates Emerge as Immune Modulators, Not Just Targeted Chemotherapy
A new review argues that antibody–drug conjugates act as immune modulators through immunogenic cell death, Fc-mediated effector functions and tumour ...
Tag: antibody-drug conjugates
Real-World Data Show Antibody-Drug Conjugate Still Works in Late-Stage Triple-Negative Breast Cancer
A multicenter Central European real-world study finds sacituzumab govitecan delivers meaningful survival benefit and manageable toxicity in heavily pretreated metastatic ...
New Wave of Targeted and Immune Therapies Reshapes Marginal Zone Lymphoma Care
A new review in Annals of Hematology details how molecular profiling and a growing arsenal of targeted and immune-based therapies ...
AI and Data Mining Take Center Stage in New Wave of Drug Discovery Research
The latest volume of SLAS Discovery showcases how artificial intelligence, deep learning and data-mining strategies are accelerating drug discovery across ...
MUC1: The Sticky Protein That Turns Guardian of Epithelia Into Engine of Cancer
A sweeping new review maps how the epithelial guardian protein MUC1, and especially its MUC1-C signaling subunit, is hijacked by ...
Global Platform Trial Aims to Transform Treatment of Children With Relapsed B-Cell Lymphoma
An international adaptive platform trial called Glo-BNHL will simultaneously test bispecific antibodies, antibody-drug conjugates and CAR T-cells in children and ...
Less Surgery, Smarter Drugs: The Trials Rewriting Breast Cancer Care in 2025
Landmark trials from 2024 and 2025 are transforming breast cancer care by safely scaling back surgery while unleashing antibody-drug conjugates, ...
Breast Tumors Shed Their HER2 Target in More Than Half of Cases After Drug Therapy
A new MD Anderson study finds that 57 percent of residual breast tumors lose HER2 overexpression after HER2-targeted neoadjuvant therapy, ...
When Cancer Type Stops Mattering: The High-Stakes Bet on Tumour-Agnostic Immunotherapy
A landmark review argues that tumour-agnostic immunotherapy succeeds only when biological rationale, validated biomarkers and health-system infrastructure are aligned, using ...
Bladder Cancer Atlas Reveals Drug Targets Switch On and Off as Tumors Mature
A single-cell atlas of 157,449 bladder cancer cells shows that antibody-drug conjugate targets rise and fall along a tumor differentiation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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