ACSS2 inhibition boosts cabozantinib activity in liver cancer models
Preclinical hepatocellular carcinoma models showed that blocking ACSS2 or autophagy enhanced cabozantinib’s antitumor activity by disrupting a TFEB-linked protective response.
Tag: animal models
Editorial reviews clinical, epidemiological and preclinical evidence on alcohol use disorder targets
A 2026 editorial synthesizes epidemiological, clinical and preclinical evidence highlighting candidate pharmacological targets for alcohol use disorder while emphasizing that ...
Preclinical Review Links Natural Compounds to PPARγ in Colitis Models
A 2026 review finds that several natural compounds alter PPARγ-related pathways in cellular and mouse models of ulcerative colitis, but ...
Smart nanoplatforms aim to make sepsis therapy responsive to disease stage
A review finds that stimulus-responsive nanoparticles can detect pathological signals in sepsis models and release antimicrobial, anti-inflammatory and immune-regulating drugs ...
Theobromine Shows Parkinson’s Promise, but Human Evidence Remains Thin
Biochemical and animal studies suggest that cocoa-derived theobromine can affect monoamine oxidase, adenosine and neuronal signaling, but no clinical evidence ...
Systematic review maps ellagic acid’s bone effects in preclinical models
A systematic review of 13 cell and animal studies reports bone-protective effects of ellagic acid in preclinical osteoporosis models, but ...
How Well Do We Actually Measure Lymphatic Function in Lymphedema Animal Models?
A new mini-review of 70 lymphedema animal studies finds that the most accessible measurements capture late-stage tissue damage rather than ...
Inside the UC Davis Testing Center Putting Lab-Grown Organoids and AI Models to the Real-World Test
The UC Davis NAMs Testing Center offers an independent, fit-for-purpose evaluation model for organoids, microphysiological systems and computational tools as ...
How Metabolic Syndrome Rewires the Bladder: Animal Models Reveal Key Mechanisms
A new review in Nature Reviews Urology synthesizes how animal models of diabetes, obesity, dyslipidaemia and hypertension reveal the mechanisms ...
Scientists Propose Framework to Test Whether Oropouche Virus Harms Fetuses
Researchers propose a combined experimental and epidemiological framework to determine whether Oropouche virus can cause vertical transmission and adverse fetal ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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