Hidden Androgen Receptor Isoform Shows Promise Against Kennedy’s Disease
A naturally occurring short isoform of the androgen receptor, AR-A, dramatically reduces aggregation and toxicity of the mutant protein causing ...
Tag: androgen receptor
Ovarian Cancer Cells May Fuel Themselves With Potent Adrenal Androgens
New research shows that high-grade serous ovarian cancer cells can convert abundant adrenal 11-oxyandrogen precursors into the potent androgen 11-keto-testosterone, ...
New R Package ChIPSP Maps Gene Regulation in 3D, Revealing Hidden Cancer Targets
Researchers have developed ChIPSP, an R package that combines ChIP-seq with Hi-C chromatin loops to identify transcription factor target genes ...
Rare Ovarian Tumor Defies Expectations With Unusual Hormone Receptor Signature
A new case report documents an ovarian microcystic stromal tumor with unusual androgen receptor and partial S100 expression, expanding the ...
Mutational Fingerprints Reveal the Hidden Forces Driving Prostate Cancer
A new Nature study integrates multiple classes of genomic mutations to define the distinct mutational processes that shape prostate cancer ...
KIF11 Inhibition Rewires Prostate Cancer Cell Identity to Restore Sensitivity to Antiandrogen Drugs
Low-dose inhibition of the motor protein KIF11 rebuilds enhancer–promoter loops at the androgen receptor locus, restoring drug sensitivity in otherwise ...
Metabolic Weaknesses Exposed in Prostate Cancer That Resists Enzalutamide
Multi-omic profiling of enzalutamide-resistant prostate cancer cells has revealed rewired lipid, glutamine and mitochondrial metabolism that creates druggable vulnerabilities and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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