Scientists Map a Battle Plan Against One of Medicine’s Rarest and Deadliest Childhood Cancers
An international expert workshop has prioritised targets and trial designs to break the three-decade therapeutic stalemate in desmoplastic small round ...
Tag: androgen receptor
Single tRNA Molecule Found to Steer Prostate Cancer Between Drug Sensitivity and Resistance
Fred Hutch researchers report in Nature that a single transfer RNA, tRNA1Arg(UCU), controls whether prostate cancer cells remain androgen receptor-dependent ...
Proteomics and machine learning expose hidden toxicity in protein degrader drugs
High-throughput proteomics and machine learning revealed that cereblon-recruiting androgen receptor degraders inhibit mitochondrial complex I, and guided linker modifications that ...
A Single tRNA Molecule Controls Whether Prostate Cancer Stays Vulnerable to Therapy
A new Nature study shows that the dosage of a single transfer RNA, tRNA1Arg(UCU), acts as a reversible molecular switch ...
Transplant Drug Rewires Prostate Tissue in Two Distinct Phases, Rat Study Finds
A new rat study shows the immunosuppressant mycophenolate mofetil dismantles prostate stromal fibers in two timed phases, reshaping collagen, immune ...
Advanced Wastewater Treatment Can Backfire, Raising Hidden Hormone Risks
A study of a Chinese wastewater treatment plant shows that UV irradiation and ozonation can raise anti-androgenic activity above a ...
How a Shifting Cast of Transcription Factors Rewires Androgen Signaling in the Aging Brain
New research shows that Alzheimer's disease disrupts androgen receptor signaling in the male brain by dismantling the collaborative transcription factor ...
Single-Cell Map Traces How Prostate Tumors Evolve to Resist Hormone Therapy
A single-cell re-analysis of 44 prostate cancer samples reveals that androgen deprivation therapy transiently activates immune programs within tumor cells ...
Hidden Androgen Receptor Isoform Shows Promise Against Kennedy’s Disease
A naturally occurring short isoform of the androgen receptor, AR-A, dramatically reduces aggregation and toxicity of the mutant protein causing ...
Ovarian Cancer Cells May Fuel Themselves With Potent Adrenal Androgens
New research shows that high-grade serous ovarian cancer cells can convert abundant adrenal 11-oxyandrogen precursors into the potent androgen 11-keto-testosterone, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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