Irish children with DADA2 show varied illness, delayed diagnoses and differing treatments
A four-child Irish case series shows how DADA2 can mimic several disorders, produce markedly different severity within one family, and ...
Tag: adenosine
Post-remission muscle loss in rheumatoid arthritis improved by dipyridamole in mice
In a mouse model of rheumatoid arthritis, dipyridamole improved persistent muscle loss and dysfunction after joint inflammation subsided, alongside restored ...
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...
Meningioma Study Points to CD73 as a Candidate Biomarker of Tumor Grade
An exploratory Brazilian study of 40 surgically resected meningiomas found that CD73 expression rises while PD-L1 falls in WHO grade ...
Radiotherapy Backfires: PD-1-Positive Monocytes Emerge as Hidden Drivers of Treatment Resistance
New research reveals that radiotherapy induces PD-1 expression on tumor-associated monocytes through an adenosine-driven signaling pathway, creating an immunosuppressive cell ...
Scientists Target the CD73-Adenosine Axis to Break Lung Cancer’s Immune Shield
A new review maps how the CD73-adenosine axis drives immune suppression in non-small cell lung cancer and how blocking it ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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