About The Study: In this cross-sectional cohort study of 170 former football players and 54 unexposed controls, larger perivascular space (PVS) volume was associated with greater exposure to repetitive head impacts (RHI). Additionally, PVS volume was associated with worse performance on cognitive tests. These findings suggest that PVS volume may contribute to the association between exposure to RHI, cognitive impairment, and the development of RHI-associated neurodegeneration.
About The Study: In this cross-sectional cohort study of 170 former football players and 54 unexposed controls, larger perivascular space (PVS) volume was associated with greater exposure to repetitive head impacts (RHI). Additionally, PVS volume was associated with worse performance on cognitive tests. These findings suggest that PVS volume may contribute to the association between exposure to RHI, cognitive impairment, and the development of RHI-associated neurodegeneration.
Corresponding Author: To contact the corresponding author, Inga K. Koerte, MD, PhD, email ikoerte@bwh.harvard.edu.
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(doi:10.1001/jamanetworkopen.2024.28687)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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