About The Study: Among adults in the intensive care unit who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions. The current evidence presents a high degree of certainty for clinicians to consider prolonged infusions as a standard of care in the management of sepsis and septic shock.
About The Study: Among adults in the intensive care unit who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions. The current evidence presents a high degree of certainty for clinicians to consider prolonged infusions as a standard of care in the management of sepsis and septic shock.
Corresponding Author: To contact the corresponding author, Jason A. Roberts, B.Pharm., Ph.D., email j.roberts@uq.edu.au.
To access the embargoed study: Visit our For The Media website at this link
(doi:10.1001/jama.2024.9803)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the Critical Care Reviews Meeting 2024.
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Journal
JAMA
Cite Scienmag News
Ophelia Keating. (June 12, 2024). Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock. Scienmag. https://scienmag.com/prolonged-vs-intermittent-infusions-of-%ce%b2-lactam-antibiotics-in-adults-with-sepsis-or-septic-shock/
Ophelia Keating. "Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock." Scienmag, 12 June 2024, https://scienmag.com/prolonged-vs-intermittent-infusions-of-%ce%b2-lactam-antibiotics-in-adults-with-sepsis-or-septic-shock/. Accessed 5 September 2026.
Ophelia Keating. "Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock." Scienmag. June 12, 2024. https://scienmag.com/prolonged-vs-intermittent-infusions-of-%ce%b2-lactam-antibiotics-in-adults-with-sepsis-or-septic-shock/
