Tuesday, August 5, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Biology

Illuminating the path to hearing recovery

April 16, 2024
in Biology
Reading Time: 3 mins read
0
Schematic diagram illustrating the activation mechanism of GPR156 in comparison with representative class C GPCRs, mGlu2, and GABAB receptors
66
SHARES
596
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT
ADVERTISEMENT

Professor Yunje Cho’s research team from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH, Republic of Korea) has collaborated with Professor Kwang Pyo Kim’s group from the Department of Applied Chemistry at Kyung Hee University (KHU, ROK), Professor Vsevolod Katritch’s team from the University of Southern California (USC, USA), and Professor Carol V. Robinson from the University of Oxford (UK) to uncover the mysteries surrounding a specific receptor protein associated with hearing. Their findings have recently been published in the online edition of Nature Structural & Molecular Biology.

Schematic diagram illustrating the activation mechanism of GPR156 in comparison with representative class C GPCRs, mGlu2, and GABAB receptors

Credit: POSTECH

Professor Yunje Cho’s research team from the Department of Life Sciences at Pohang University of Science and Technology (POSTECH, Republic of Korea) has collaborated with Professor Kwang Pyo Kim’s group from the Department of Applied Chemistry at Kyung Hee University (KHU, ROK), Professor Vsevolod Katritch’s team from the University of Southern California (USC, USA), and Professor Carol V. Robinson from the University of Oxford (UK) to uncover the mysteries surrounding a specific receptor protein associated with hearing. Their findings have recently been published in the online edition of Nature Structural & Molecular Biology.

 

Deep within the inner ear lie the cochlea, responsible for sound detection, and the vestibular apparatus, which oversees balance. Cells within these regions harbor a class C orphan G-protein-coupled receptor (GPCR) called GPR156. When this receptor is activated, it binds with G-proteins inside the cell, facilitating signal transmission. Unlike its counterparts, GPR156 exhibits sustained activity even in the absence of external stimuli, playing a pivotal role in upholding auditory and balance functions. Unveiling the structural and functional intricacies of GPR156 holds promise for devising interventions for individuals with congenital hearing impairments.

 

The research team employed cryo-electron microscopy (cryo-EM) analysis to delve into the GPR156 in the Go-free and Go-coupled states, achieving unprecedented resolution. Their investigation unearthed the mechanisms behind GPR156’s ability to maintain heightened activity sans activators.

 

Their analysis confirmed that GPR156 activation hinges on its interaction with abundant lipids in the cell membrane, triggering structural shifts upon engagement with G-proteins in the cytoplasm. Notably, unlike conventional GPCRs, GPR156 exhibits flexibility in altering the structure of the seventh helix as it traverses the cell membrane, thereby facilitating binding with G-proteins and orchestrating signal activation to detect sound. This study represents a crucial step forward in unraveling the structural dynamics and activation mechanisms of GPR156.

 

Professor Yunje Cho of POSTECH remarked, “Congenital hearing and balance impairments afflict numerous individuals. I am hopeful that our research will pave the way for groundbreaking treatments and drug discoveries to alleviate their suffering.”

 

This research received financial support from the National Research Foundation of Korea.



Journal

Nature Structural & Molecular Biology

DOI

10.1038/s41594-024-01224-7

Article Title

Constitutive activation mechanism of a class C GPCR

Article Publication Date

8-Feb-2024

Share26Tweet17
Previous Post

The Lancet: Many people with breast cancer ‘systematically left behind’ due to inaction on inequities and hidden suffering

Next Post

Australian media need generative AI policies to help navigate misinformation and disinformation

Related Posts

blank
Biology

Unveiling NUDIX Hydrolase in Leishmania major

August 5, 2025
blank
Biology

Quinoa Terpenoids Inhibit Breast Cancer Migration via miR-21-5p

August 5, 2025
blank
Biology

Methanotroph Methylotuvimicrobium: Transcriptomic Insights into Fumarate Production

August 5, 2025
blank
Biology

Nanoflowers Offer New Hope for Healing Brain Cells and Combating Neurodegenerative Diseases

August 5, 2025
blank
Biology

New Trematode Species Found in Mediterranean Cardinal Fish

August 5, 2025
blank
Biology

Ultrasound L-Lysine Boosts Pork Color Stability

August 5, 2025
Next Post

Australian media need generative AI policies to help navigate misinformation and disinformation

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27530 shares
    Share 11009 Tweet 6881
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    941 shares
    Share 376 Tweet 235
  • Bee body mass, pathogens and local climate influence heat tolerance

    641 shares
    Share 256 Tweet 160
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    506 shares
    Share 202 Tweet 127
  • Warm seawater speeding up melting of ‘Doomsday Glacier,’ scientists warn

    310 shares
    Share 124 Tweet 78
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Urban Rituals Halted: COVID-19 Lockdowns Impact Celebrations
  • Canadian Parents’ Views on Micro- and Nanoplastics
  • Unveiling NUDIX Hydrolase in Leishmania major
  • Computational Biology Designs Custom Binders to Outsmart Cancer

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,184 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading