Amid escalating global crises ranging from emerging infectious diseases to alarming antimicrobial resistance, the international scientific community is advocating for an unprecedented integrative paradigm shift to confront these complex, interdependent challenges. The recent Crete Declaration, orchestrated by a consortium of Europe’s foremost biodiversity, ecology, and engineering research infrastructures under the aegis of LifeWatch European Research Infrastructure Consortium (ERIC), heralds this transformative approach centered around the One Health framework. This initiative emphasizes the inseparability of human, animal, and ecosystem health, demanding innovative, evidence-based policy integration and cross-disciplinary collaboration.
The intricate nexus of health risks we face today—exemplified by zoonotic spillovers, environmental contamination, and biodiversity loss—is compounded and exacerbated by the accelerating impacts of climate change. Recognizing this, the Crete Declaration delineates a holistic, systemic strategy that prioritizes the fusion of data, expertise, and operational frameworks from disparate scientific domains. Such an approach endeavors to foster resilience while generating actionable insights that can drive robust, adaptive policy responses across Europe and beyond.
Foremost in this collective effort is the acknowledgment of research infrastructures as pivotal actors uniquely poised to synthesize vast and heterogeneous datasets encompassing molecular biology, ecosystem dynamics, and socio-economic parameters. Through the integration of cutting-edge technologies and shared platforms, these infrastructures enable seamless data interoperability guided by the FAIR (Findable, Accessible, Interoperable, Reusable) Principles. This guarantees that datasets, analytical workflows, and software tools transcend traditional silos, facilitating a transdisciplinary research ecosystem capable of addressing multidimensional One Health challenges.
The Declaration underscores the importance of advancing open science and open innovation as critical mechanisms for societal and technological transformation. By advocating for transparent data sharing and collaborative development processes, the initiative seeks to democratize access to scientific resources, thereby accelerating the co-creation of novel solutions. This approach also promotes inclusivity, ensuring that stakeholders across policy, academia, industry, and civil society collectively shape research agendas in alignment with societal needs and ethical frameworks.
Central to the Declaration’s vision is the integration of emerging methodologies such as artificial intelligence (AI) and machine learning within One Health applications. The responsible deployment of AI-driven analytics promises to revolutionize disease surveillance, environmental monitoring, and predictive modeling, thus enhancing early warning capacities and targeted interventions. The signatories emphasize the necessity of embedding robust ethical considerations, transparency, and interoperability standards when implementing AI to maximize benefits while mitigating risks.
Moreover, the Crete Declaration articulates a strategic roadmap to fortify Europe’s role as a global leader in One Health research. This involves consolidating cross-domain expertise to furnish policymakers with scientifically rigorous evidence that underpins effective, forward-looking regulations and initiatives. Such evidence-based policymaking is envisioned as foundational to advancing sustainable management of natural resources, safeguarding food and water security, and bolstering societal resilience against biological and environmental stressors.
The facilitation of a trusted, inclusive platform for stakeholder engagement lies at the heart of the initiative’s commitment to participatory governance. By fostering dialogue among researchers, policymakers, industry leaders, and local communities, the Declaration promotes transparency and shared ownership of One Health objectives. This collaborative ethos strengthens the social legitimacy and adoption of innovative policies while enabling rapid feedback loops critical for adaptive management.
The genesis of the Declaration during a special assembly held in Crete underscores the concerted effort to align diverse European institutions around a common strategic vision. Hosted by the Institute of Marine Biology, Biotechnology and Aquaculture at the Hellenic Centre for Marine Research, this event catalyzed consensus on the pivotal role of integrated scientific infrastructures in tackling pressing biosphere challenges. It also framed a coordinated approach to scaling up One Health initiatives through federated networks underpinned by harmonized data governance.
Importantly, the Declaration signals an open invitation to a broad spectrum of stakeholders—including science clusters, governmental bodies, and the private sector—to endorse and actively participate in forging a resilient, cohesive European One Health research community. This collective endeavor aspires not only to enhance the continent’s scientific and policy capacities but also to provide scalable models adaptable to global contexts. The interoperable frameworks and shared infrastructures championed herein exemplify best practices in transnational cooperation for complex problem solving.
In its strategic working plan, LifeWatch ERIC consolidates these ambitions by integrating research outputs into a comprehensive open science collection hosted by the journal Research Ideas and Outcomes. This repository functions as a vital knowledge base offering seamless access to significant deliverables, fostering transparency, reproducibility, and accelerated innovation pipelines. The Crete Declaration thus emerges as both a milestone and a call to action, reinforcing the urgency for systemic systemic solutions grounded in interdisciplinary science.
Collectively, the Crete Declaration envisions a future where scientific rigor, technological advancement, and participatory governance converge to holistically safeguard the biosphere’s health. This model transcends conventional disciplinary boundaries and embraces complexity, forging pathways to sustainable coexistence amid escalating planetary pressures. By embedding resilience through data-driven insights and inclusive collaboration, the initiative positions Europe at the forefront of a truly integrative One Health revolution.
The journey ahead requires sustained commitments to data integration, ethical innovation, and equitable resource sharing. As climate change continues reshaping ecological and epidemiological landscapes, such an assertive, unified scientific front becomes indispensable. The Crete Declaration crystallizes this imperative, providing a blueprint for leveraging Europe’s intellectual and infrastructural assets to catalyze transformative change with far-reaching societal impact.
Europe’s pledge to advance One Health through the Crete Declaration thus constitutes a pioneering framework aimed at harmonizing research infrastructures, optimizing open science tools, and embedding stakeholder inclusion. It challenges existing paradigms by promoting systemic understanding and action, thereby defining a new era of scientific leadership dedicated to planetary health resilience and sustainable development.
Subject of Research: One Health approach integrating biodiversity, ecology, and engineering research infrastructures to address global health, environmental, and societal challenges.
Article Title: The Crete Declaration: Uniting Science for One Health
News Publication Date: 4-Nov-2025
Web References:
- LifeWatch European Research Infrastructure Consortium (ERIC): https://www.lifewatch.eu/
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One Health information by WHO: https://www.who.int/health-topics/one-health#tab=tab_1
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FAIR Principles: https://www.go-fair.org/fair-principles/
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Research Ideas and Outcomes journal: https://riojournal.com/
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DOI link to article: http://dx.doi.org/10.3897/rio.11.e176120
References:
Arvanitidis C, Ameixa O, Basset A, Chatzinikolaou E, Coman C, Companys B, De Leo F, Deneudt K, Drago F, Eriksson J, Ferrari T, Georgiev T, Giuliano G, Gruber S, Habermann J, Heil K, Hubbard T, Huertas Olivares C, Kotoulas G, Koureas D, Manola N, Marrocco V, Pade N, Portugal Melo A, Provenzale A, Psomopoulos F, Raes N, Robinson S, Ruch P, Schaap D, Stanica A, Stavropoulos T, Teixeira H, van Tienderen P, Tsigenopoulos C, Waterhouse R, Aprea G, Boër M, Casino A, Delauney L, Ewbank J, Mirtl M, Pavlic-Zupanc J, Penev L, Piera J, Pitta P, Puillat I, Richter D, Stepanyan D, Ussi A, Węsławski J, Zuquim G (2025) The Crete Declaration: Uniting Science for One Health. Research Ideas and Outcomes 11: e176120.
Keywords: One Health, biodiversity, environmental contamination, antimicrobial resistance, climate change, data integration, FAIR principles, open science, artificial intelligence, interdisciplinary research, policy innovation, LifeWatch ERIC, research infrastructures, ecosystem health.
