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Home Science News Cancer

Detecting Colorectal Cancer Using Smartphone Technology

June 5, 2025
in Cancer
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Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, yet early detection through effective screening significantly improves patient outcomes. In Germany, however, participation in colorectal cancer screening programs remains suboptimal, particularly concerning the use of fecal immunochemical testing (FIT) — a non-invasive test designed to detect minute traces of blood in stool, which may indicate the presence of malignancies or precancerous lesions. Recognizing the potential to revolutionize screening uptake, researchers at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have embarked on an innovative investigation: could integrating smartphone technology with FITs offer a more accessible and user-friendly alternative to conventional laboratory testing?

Traditional colorectal cancer screening options in Germany primarily include colonoscopy and FIT, both targeting men and women aged 50 and older. Colonoscopy is widely regarded as the gold standard for early detection due to its superior accuracy and the opportunity it provides for immediate removal of precancerous polyps. Nonetheless, many individuals decline colonoscopy due to its invasive nature, leading to the recommendation of FIT as a secondary screening method. FIT uses antibodies specific to hemoglobin, the oxygen-carrying component of blood, to chemically identify occult blood in stool samples — a potential marker for colorectal neoplasia. Despite the test’s non-invasive convenience, only around 20% of the eligible German population currently engage in regular FIT screening, starkly contrasting with countries like the Netherlands, where over 70% adherence is observed.

The underutilization of FIT in Germany prompted DKFZ scientists, led by Michael Hoffmeister, to explore digital health solutions that could lower participation barriers. The ubiquity of smartphones, now entrenched in daily life for a majority of the population, inspired the concept of coupling a rapid hemoglobin detection test with a smartphone app, potentially transforming stool analysis from a lab-dependent process into a rapid, decentralized, and patient-controlled procedure. The smartphone-based system employs a commercially available rapid hemoglobin test administered at home. Users collect stool samples, dip a test stick into the sample multiple times, immerse the stick into a reagent tube, and apply drops of the prepared solution onto a test cassette. After a 15-minute reaction period, the user photographs the cassette with their smartphone. The accompanying app interprets the image’s color intensity to determine the presence or absence of occult blood, providing immediate results on the device screen without needing laboratory involvement or delay.

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Central to the viability of this approach is the test’s analytical performance compared to traditional laboratory FITs. To validate this, the DKFZ coordinated a population-based study, known as the BLITZ study, from 2021 to 2023 targeting individuals scheduled for colonoscopy in southern Germany. The study enrolled 654 participants who were invited to concurrently perform both the conventional FIT and the smartphone-based stool test. Over half of these participants (55%) opted to undertake the smartphone-based test, demonstrating initial patient acceptance, and 89% of them later affirmed in questionnaires that they found the smartphone testing method to be a valuable alternative.

Quantitative comparisons revealed that the smartphone-based FIT demonstrated sensitivity and specificity metrics nearly equivalent to traditional laboratory testing. When assessed against colonoscopy findings — the diagnostic gold standard — the app identified advanced and potentially malignant mucosal lesions with a sensitivity of 28%, while the laboratory-based FIT showed a slightly higher sensitivity of 34%. Both testing modalities boasted a specificity of 92%, indicating an identical low rate of false positives. These results attest that the smartphone app does not compromise diagnostic accuracy while enhancing ease of use and convenience.

The implications of these findings are profound. By offering a patient-friendly and digitally enabled screening method, the smartphone-based FIT system could significantly broaden colorectal cancer screening participation among populations reluctant or unable to undergo colonoscopy or traditional FIT. As Hoffmeister explains, “Leveraging the power and familiarity of smartphones can lower psychological and practical barriers, empowering more individuals to partake in important early cancer detection measures.” Co-author Herrmann Brenner highlights the realistic prospect that the additional screening option may ultimately increase uptake rates and thereby provide more opportunities for timely colorectal cancer prevention.

Beyond the clinical data, the smartphone FIT paradigm also aligns well with broader trends in digital health and personalized medicine. Remote diagnostics that integrate seamlessly with everyday technology represent a progressive shift from centralized laboratory dependence toward distributed, patient-centered care models. This innovation supports the democratization of healthcare data, enhancing rapid feedback loops and potentially allowing real-time monitoring of patient health statuses.

However, several technical and implementation challenges remain to be addressed before mass adoption. The reproducibility of smartphone image analysis across diverse lighting conditions and device camera qualities warrants further optimization. Ensuring user compliance with correct test administration protocols and secure data privacy management through the app’s software infrastructure is essential. Additionally, integration of results within healthcare systems for follow-up and intervention will require coordination among primary care, gastroenterology, and digital health providers.

Nonetheless, the DKFZ’s pioneering work establishes a solid foundation for the transformation of colorectal cancer screening. The study, published in Clinical Gastroenterology and Hepatology, marks a significant milestone demonstrating that smartphone-based stool testing can deliver sensitivity and specificity on par with laboratory methods while enhancing accessibility and patient acceptability. As the global healthcare community continues to embrace telemedicine and mobile diagnostics, such innovations are set to redefine how early cancer detection is approached—not merely in Germany but worldwide.

The German Cancer Research Center (DKFZ), Germany’s largest biomedical research institute with more than 3,000 employees, continues to be at the forefront of cancer research and translational medicine. With its collaborative network that includes the National Center for Tumor Diseases and the German Cancer Consortium, DKFZ is instrumental in developing new cancer prevention strategies, improving diagnostic precision, and advancing successful treatment protocols. The initiative to evaluate and develop smartphone-based colorectal cancer screening exemplifies how cutting-edge research can be integrated with emerging technologies to create practical solutions addressing public health challenges.

In conclusion, the intersection of immunological stool testing and mobile technology presents a promising avenue for enhancing colorectal cancer screening uptake and efficacy. The DKFZ’s research underscores that a well-designed smartphone-based FIT test not only matches traditional laboratory tests in diagnostic accuracy but also significantly improves patient convenience and empowerment. As healthcare systems strive to increase preventive care participation and reduce cancer burden, such digital health innovations offer a glimpse into the future of accessible, reliable, and patient-centered cancer diagnostics.


Subject of Research: Smartphone-based fecal immunochemical testing (FIT) for colorectal cancer screening

Article Title: Performance of a smartphone-based stool test for use in colorectal cancer screening: population-based study

News Publication Date: Not explicitly stated; study period 2021-2023, publication in 2025

Web References:
https://doi.org/10.1016/j.cgh.2025.04.027

References:
Hoffmeister M, Seum T, Ludwig L, Brenner H: Performance of a smartphone-based stool test for use in colorectal cancer screening: population-based study. Clin Gastroenterol Hepatol 2025

Keywords: Health and medicine, colorectal cancer, screening, fecal immunochemical test, FIT, smartphone diagnostics, digital health, cancer prevention

Tags: blood detection in stoolCancer mortality reductioncolonoscopy alternativescolorectal cancer detectioncolorectal cancer screening programsearly cancer screening methodsfecal immunochemical testingGerman Cancer Research Centerimproving screening participationnon-invasive cancer screeningsmartphone technology in healthcareuser-friendly health solutions
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