cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy

Subject of Research: Medicine

Article Title: cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy

Article References: Huang, Y., Fan, L., Wong, M. Y., Lei, Z., Krishnamachary, B., Zhu, D., Cadiz, M. P., Nagiri, R. K., Ye, P., Norman, K., Bhagwat, M., Lee, Y. J., Li, H., Zhu, J., Amin, S., Lauderdale, K., Chen, H., Luo, W., Gong, S., ... Gan, L. (2026). cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy. Nature Neuroscience. https://doi.org/10.1038/s41593-026-02384-z

Image Credits: AI Generated

DOI: 10.1038/s41593-026-02384-z

Keywords: cGAS-mediated immune response in epilepsy, disease progression in refractory epilepsy, immune-mediated neurodegeneration, innate immune pathways in neurological disorders, innate immunity and seizure disorders, molecular mechanisms of drug-refractory epilepsy, neuroimmune interactions in epilepsy, neuroinflammation and epilepsy progression, neuroinflammatory signaling pathways, role of cGAS-STING pathway in epilepsy, therapeutic targets for drug-resistant epilepsy, type I interferon signaling in drug-resistant epilepsy