Cancer
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive...
Blocking a Single Kinase May Steer Immune Cells Toward Safer Atherosclerotic Plaques
New research shows that removing protein kinase C delta reprograms macrophage metabolism to suppress inflammatory pyroptotic cell death and stabilize...
ATR Inhibitors Supercharge Bladder Cancer Chemotherapy in Patient-Derived Organoids
Dutch researchers have shown that combining the bladder chemotherapy drug mitomycin C with ATR kinase inhibitors eradicates patient-derived non-muscle invasive...
Beyond KRAS G12C: New Drug Wave Targets Once-Undruggable Cancer Driver
A new review maps the fast-moving landscape of next-generation KRAS inhibitors, degraders, and combination strategies now advancing beyond the first...
Glutamine Joins Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Cancer Trial
The phase 1 GlutaPanc trial shows that l-glutamine can be safely combined with first-line gemcitabine and nab-paclitaxel in advanced pancreatic...
Cancer Drug Lapatinib Offers Safer HER2 Route for Patients With Failing Hearts
A new clinical case report shows that the oral HER2 inhibitor lapatinib, with its short half-life and low cardiac toxicity,...
Thyroid Cancer Protein Rewires Tumor Metabolism and Drives Drug Resistance
New research shows the protein ECT2 drives papillary thyroid carcinoma growth by suppressing lipoic acid metabolism, activating PI3K/AKT signaling and...
Gene Mutations After Surgery Predict Lung Cancer Recurrence Risk in Large Chinese Cohort
A retrospective cohort study of 1,674 Chinese lung cancer patients identifies TP53 and TP53-MET co-mutations as independent predictors of poorer...
RNA Profiling Splits Deadly Dog Spleen Cancer into Three Actionable Subtypes
Researchers at the University of São Paulo used a qPCR-based gene expression panel to divide canine splenic hemangiosarcoma into three...
Breast Cancer Is Striking Later in Life—But Only for the Rich, 47-Year Study Finds
A 46-year SEER analysis of nearly 700,000 breast cancer patients shows the rise in age at diagnosis is concentrated among...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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