Cancer
Armoured GPC3 CAR T Cells Show Promise Against Liver Cancer, but Hurdles Remain
An armoured GPC3-targeted CAR T cell therapy engineered to resist TGFβ-mediated immunosuppression showed promising initial results in 36 patients with...
Immunotherapy Brings Hope to Liver Cancer Patients, but One-Third Who Stop Treatment Face Rising Regret
A Taiwanese mixed-methods study finds that liver cancer patients who complete six cycles of immunotherapy maintain stable quality of life,...
Invasive Lobular Carcinoma Research Takes Center Stage at 7th International Symposium
Selected abstracts from the seventh biannual International Invasive Lobular Carcinoma Symposium, published in Breast Cancer Research and Treatment, showcase the...
CROWN AI Model Masters More Than 200 Cytology Tasks With Expert-Level Accuracy
Researchers have developed CROWN, a self-supervised visual foundation model pretrained on more than ten million cytology images that achieved top...
Where does the immune pressure go? New framework explains immunotherapy resistance
A new Molecular Cancer review proposes immune-pressure redistribution as a unifying framework explaining why patients resist PD-1/PD-L1 blockade and how...
Calcium-Rich Bone Environment Helps Osteosarcoma Cells Survive Chemotherapy
Researchers have discovered that the calcium-rich bone microenvironment drives chemotherapy tolerance in osteosarcoma through an ORAI3–Ca²⁺–NFAT4–PINK1 mitophagy axis that can...
Vitamin B12 Deficiency Emerges as Hidden Burden in Gut Graft-Versus-Host Disease After Stem Cell Transplants
A retrospective study of 341 stem cell transplant recipients finds that nearly half develop vitamin B12 deficiency, with the deficit...
Ultrasound Right After Childhood Kidney Biopsy Predicts Dangerous Bleeding, Study Finds
A Canadian retrospective study of 207 children found that a perinephric hematoma of at least five milliliters on immediate post-biopsy...
New Single-Cell Framework Maps How Myeloid Cells Shape Cancer Immunity
Researchers have built an open-source single-cell framework that maps injury, resolution and antigen-presentation programs in tumor myeloid cells across cancers.
Leadership, Not Resilience Training, May Be the Key to Curing Physician Burnout
A new commentary in Pediatric Radiology argues that burnout is driven by organizational systems rather than individual resilience deficits, and...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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