Cancer
New National Standards Aim to Fix Fragmented Cancer Survivorship Care
Early results from 18 NCI-funded demonstration projects reveal both the promise and the practical challenges of implementing the new National...
ESR1 Testing Stays Rare in Metastatic Breast Cancer Even as Mutations Emerge
A real-world study of over 8,500 US patients with ER-positive/HER2-negative metastatic breast cancer found that ESR1 mutation testing remains rare...
Scientists Map the Master Plan for Rebuilding the Human Gut with Stem Cells
A landmark roadmap from the NIH-backed Intestinal Stem Cell Consortium details how intestinal stem cells and their niches could be...
Single-Cell Multi-Omics Reveals How Cancer Clones Evolve Genotype and Phenotype Together
A Nature Reviews Cancer review explains how genotype-aware single-cell multi-omics and phylogenetic reconstruction are revealing how mutant clones in healthy...
KIF11 Inhibition Rewires Prostate Cancer Cell Identity to Restore Sensitivity to Antiandrogen Drugs
Low-dose inhibition of the motor protein KIF11 rebuilds enhancer–promoter loops at the androgen receptor locus, restoring drug sensitivity in otherwise...
Hidden Protein Modification Lets Pancreatic Cancer Evade Ferroptosis and Resist Chemotherapy
A new Nature Cancer study reveals how hypoxia-induced lactylation of MMSDH triggers ACSL4 degradation through propionylation, helping pancreatic cancer evade...
New Gene Therapy Approach Transforms Scar-Forming Astrocytes Into Working Motor Neurons
Researchers report that a technique called TRANsCre-DIONE can convert scar-forming reactive astrocytes into functional motor neurons, a result with implications...
Ruxolitinib Shows Stronger Response in Primary Than Secondary HLH, Meta-Analysis Finds
A systematic review of 542 patients finds ruxolitinib-based regimens achieve an 87.2 percent overall response rate in hemophagocytic lymphohistiocytosis, with...
Gene Therapy Shows Durable Power Against Blinding Retinal Disease, Major Analysis Finds
A systematic review and meta-analysis of 25 studies finds that ocular gene therapy significantly suppresses retinal neovascularization and vascular leakage...
AI Maps a Hidden Neutrophil Niche in Lung Cancer and Flags a New Drug Target
A deep learning pipeline integrating single-cell and spatial transcriptomics has revealed an OSM-primed neutrophil niche that sustains aggressive mesenchymal tumor...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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