Cancer
KIF11 Inhibition Rewires Prostate Cancer Cell Identity to Restore Sensitivity to Antiandrogen Drugs
Low-dose inhibition of the motor protein KIF11 rebuilds enhancer–promoter loops at the androgen receptor locus, restoring drug sensitivity in otherwise...
Hidden Protein Modification Lets Pancreatic Cancer Evade Ferroptosis and Resist Chemotherapy
A new Nature Cancer study reveals how hypoxia-induced lactylation of MMSDH triggers ACSL4 degradation through propionylation, helping pancreatic cancer evade...
New Gene Therapy Approach Transforms Scar-Forming Astrocytes Into Working Motor Neurons
Researchers report that a technique called TRANsCre-DIONE can convert scar-forming reactive astrocytes into functional motor neurons, a result with implications...
Ruxolitinib Shows Stronger Response in Primary Than Secondary HLH, Meta-Analysis Finds
A systematic review of 542 patients finds ruxolitinib-based regimens achieve an 87.2 percent overall response rate in hemophagocytic lymphohistiocytosis, with...
Gene Therapy Shows Durable Power Against Blinding Retinal Disease, Major Analysis Finds
A systematic review and meta-analysis of 25 studies finds that ocular gene therapy significantly suppresses retinal neovascularization and vascular leakage...
AI Maps a Hidden Neutrophil Niche in Lung Cancer and Flags a New Drug Target
A deep learning pipeline integrating single-cell and spatial transcriptomics has revealed an OSM-primed neutrophil niche that sustains aggressive mesenchymal tumor...
Scientists Target the CD73-Adenosine Axis to Break Lung Cancer’s Immune Shield
A new review maps how the CD73-adenosine axis drives immune suppression in non-small cell lung cancer and how blocking it...
Ultrasound Atlas of Healthy Childhood Entheses Could Transform Juvenile Arthritis Diagnosis
A pilot ultrasound study of 79 healthy children maps normal thickness and blood-flow patterns at ten lower-extremity entheses, showing that...
Body Composition May Predict Chemotherapy Toxicity in Early-Stage Breast Cancer
A new review finds that muscle mass, fat distribution, and sarcopenic obesity strongly influence chemotherapy toxicity in early-stage breast cancer,...
Interventional Oncology 2030: AI, Hybrid Suites and the Next Generation
The inaugural Thierry de Baère Lecture maps five domains, from artificial intelligence to mentorship, that will define interventional oncology by...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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