Saturday, August 30, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

Breast cancer risk variants identified for women of African ancestry

May 13, 2024
in Cancer
Reading Time: 3 mins read
0
Dr. Wei Zheng
66
SHARES
597
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

A study led by researchers from Vanderbilt-Ingram Cancer Center sheds light on some of the genetic variants that make breast cancer more deadly for women of African ancestry and significantly reduces the disparity in knowledge for assessing their genomic risk factors.

Dr. Wei Zheng

Credit: Vanderbilt University Medical Center

A study led by researchers from Vanderbilt-Ingram Cancer Center sheds light on some of the genetic variants that make breast cancer more deadly for women of African ancestry and significantly reduces the disparity in knowledge for assessing their genomic risk factors.

 

The study, published in Nature Genetics, is the largest genome-wide association study ever conducted among women of African ancestry for breast cancer, the researchers said. Analyzing 18,034 cases and 22,104 controls of African ancestry, they identified genetic variants at 12 loci associated with breast cancer risk at the genome-wide significant level. Of them, variants in three loci were associated with risk of triple-negative breast cancer (TNBC). Approximately 8% of African-ancestry women carry all six risk variants in these loci, and these women are 4.2 times more likely to be diagnosed with TNBC than those who carry none or only one of the variants.

 

The new data put women of African ancestry on a more equitable status with women of European and Asian ancestry for deriving breast cancer polygenic risk scores (PRS) — a calculation based on genetic markers and variants for assessing cancer susceptibility. Including the newly identified genomic markers into PRS analyses significantly improved the performance of the prediction of breast cancer risk for women of African ancestry.

 

“We have worked with researchers from more than 15 institutions in the U.S. and Africa to establish this large genetic consortium. Data put together in this consortium have been and will continue to be used by researchers around the world to address significant questions related to breast cancer etiology and genetics,” said the study’s corresponding author Wei Zheng, MD, PhD, MPH, the Anne Potter Wilson Professor of Medicine and director of the Vanderbilt Epidemiology Center.

 

Breast cancer is the most commonly diagnosed cancer among women in the United States, and TNBC is a more aggressive subtype that women of West African ancestry are more likely to develop than women of other ethnic backgrounds.

 

Guochong Jia, PhD, MPH, a postdoctoral fellow at Vanderbilt University Medical Center, is the study’s lead author.

 

Other Vanderbilt authors on the study are Jie Ping, PhD, Xingyi Guo, PhD, Ran Tao, PhD, Bingshan Li, PhD, Xiao-Ou Shu, MD, PhD, MPH, Tuya Pal, MD, Sonya Reid, MD, MPH, Oiuyin Cai, MD, PhD, and Jirong Long, PhD.

 

The Vanderbilt researchers received support from the U.S. National Institutes of Health (R01 CA202981) (R01 CA235553).  

 

 



Journal

Nature Genetics

DOI

10.1038/s41588-024-01736-4

Article Title

Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction

Article Publication Date

13-May-2024

Share26Tweet17
Previous Post

Healing faster: Unveiling the future of tissue & organ repair

Next Post

In a reservoir in Southeast Brazil, introduction of a fish native to the Amazon has reduced native species diversity

Related Posts

blank
Cancer

Cancer Treatment’s Impact on Breast Cancer Survivors

August 30, 2025
blank
Cancer

Revisiting Conversion Therapy for Pancreatic Cancer Metastasis

August 30, 2025
blank
Cancer

New Oncology Network Advances GI Cancer Care

August 30, 2025
blank
Cancer

Gastrectomy Methods Compared After Chemotherapy

August 30, 2025
blank
Cancer

AI Uncovers Glycolytic Diversity in Colorectal Cancer

August 30, 2025
blank
Cancer

Pyrogallol Nanocomposite Mitigates Radiation Damage via miRNA

August 30, 2025
Next Post
In a reservoir in Southeast Brazil, introduction of a fish native to the Amazon has reduced native species diversity

In a reservoir in Southeast Brazil, introduction of a fish native to the Amazon has reduced native species diversity

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27542 shares
    Share 11014 Tweet 6884
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    955 shares
    Share 382 Tweet 239
  • Bee body mass, pathogens and local climate influence heat tolerance

    642 shares
    Share 257 Tweet 161
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    509 shares
    Share 204 Tweet 127
  • Warm seawater speeding up melting of ‘Doomsday Glacier,’ scientists warn

    312 shares
    Share 125 Tweet 78
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Predictive Models for Assessing Substituted Benzene Pollution
  • Animal Models Reveal PTSD Resilience and Vulnerability Differences
  • MK801 Reduces Secondary Injury in Spinal Cord Trauma
  • Odor Compounds in Qiandaohu: Patterns and Controls

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Blog
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,182 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading