Population-based Monastir cohort links early-stage breast cancer with lower 10-year mortality
A population-based cohort of women diagnosed in Monastir from 2002–2014 found that stage 0–II breast cancer was associated with lower...
CCL21-ICAM1 synthetic niche accelerates lytic hit delivery by OT-I T cells against B16 melanoma in vitro
In a two-dimensional mouse-cell study, CCL21-ICAM1 conditioning was associated with an approximately fourfold increase in the model-estimated lytic hit-delivery rate...
Cell study finds IL-1β amplifies TGF-β1 effects in SK-Hep1 cells through p38 MAPK-linked SMAD2/3 signaling
An in vitro SK-Hep1 cell study found that IL-1β enhanced TGF-β1-induced fibronectin and N-cadherin expression, migration and invasion through a...
CT co-registration yields more stable D90 verification in 30-patient retrospective lung cancer study
A retrospective study in 30 lung cancer patients found that CT co-registration produced postoperative D90 estimates more consistent with the...
Randomized phase III trial with a factorial design assessing the efficacy and safety of darolutamide and stereotactic dose-escalated radiotherapy in patients with high-risk localized prostate cancer: the PEACE 7 (GETUG-AFU 45) study protocol
The PEACE 7 protocol plans a 700-patient phase III trial testing darolutamide and a prostate stereotactic radiotherapy boost in men...
Cell assays and molecular modeling assess 1,2,3-thiadiazole derivatives against cancer cell lines
A cell-based and computational study found compound 5g had the highest measured cytotoxic activity in most tested cancer cell lines...
Case-control study links VEGFA rs833061 variants with bladder cancer and serum YKL-40
A hospital-based case-control study of 120 bladder cancer patients and 120 matched controls found adjusted associations between VEGFA rs833061 genotypes,...
METTL14 stabilizes FDX1 RNA and restrains clear cell kidney cancer
Preclinical experiments show that METTL14 stabilizes FDX1 RNA through m6A methylation, promoting cuproptosis and suppressing clear cell renal cell carcinoma...
Hupehenine targets an inflammatory pathway linked to diabetes and colorectal cancer
Hupehenine bound three proteins in an inflammation-linked pathway, reduced colorectal cancer cell phenotypes and shifted macrophage markers in a laboratory...
Ethiopian case-control study yields internally validated lung cancer risk model
An Ethiopian case-control study developed and internally validated a lung cancer risk model with an AUC of 0.775, while external...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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