ROS1 Fusion Subtype Shapes Survival in Advanced Lung Cancer, Real-World Data Show
A real-world study of 55 patients with advanced ROS1-rearranged non-small cell lung cancer shows that fusion subtype, PD-L1 expression and...
Mutational Fingerprints Reveal the Hidden Forces Driving Prostate Cancer
A new Nature study integrates multiple classes of genomic mutations to define the distinct mutational processes that shape prostate cancer...
Triple-Drug Antibody-Drug Conjugate Strategy Shows Promise in Hard-to-Treat Breast Cancer
A real-world study of 87 patients suggests that combining Trop-2 antibody-drug conjugates with PD-1 inhibitors and anti-angiogenic therapy substantially improves...
Dogs May Not Respond to Thalidomide, Genetic Study Warns
Genomic analysis of nearly 2,000 dogs reveals that they carry the same cereblon variation that makes mice insensitive to thalidomide,...
Arthritis Drug Diacerein Shows Surprising Power Against Deadly Brain Cancer
Researchers report that the osteoarthritis drug diacerein kills glioma cells by triggering caspase-3 and GSDME-mediated pyroptosis, revealing a new drug-repurposing...
Plant Compound Diosgenin Emerges as Powerful Computational Anti-Cancer Candidate
A computational screen of 698 plant compounds identified diosgenin as a stronger and safer binder of antiapoptotic Bcl-2 family proteins...
Early-Onset Cancers Are Rising Across the Nordic Countries, Landmark 20-Year Study Finds
A comprehensive analysis of Nordic cancer registry data from 2003 to 2022 shows incidence rates rising for 12 of 18...
Hidden RNA Switch Helps Esophageal Cancer Evade Ferroptotic Cell Death
A new study reveals that the m6A-stabilized long non-coding RNA SSTR5-AS1 helps esophageal cancer cells resist ferroptosis by recruiting FAM120A...
Six Months of Chemotherapy Before Surgery Matches Four-Month Course in Pancreatic Cancer
The PACT-21/CASSANDRA phase 3 trial found that six months of preoperative chemotherapy produced event-free survival comparable to a four-month preoperative...
AI Scours 1.2 Million Natural Products to Find Fungal Compound That Starves Glioblastoma of Cholesterol
An AI-driven screening pipeline identified the fungal sterol 5,6-epoxyergosterol as a selective LXRβ agonist that exploits the cholesterol dependency of...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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