Alpha Versus Beta: Tumor Architecture Decides Where Radiation Dose Lands
Monte Carlo simulations show astatine-211 delivers about 120-fold higher single-cell nuclear dose than lutetium-177, but its effectiveness depends strongly on...
AhR blockade rewires myeloid–T cell crosstalk and boosts anti-PD-1 response in preclinical tumor models
Preclinical research shows that blocking the aryl hydrocarbon receptor reshapes myeloid–T cell crosstalk and enhances anti-PD-1 responses across mouse and...
Sub-Voxel MRI Technique Maps Distinct Magnetic Susceptibility Patterns Across Glioma Subregions
A sub-voxel quantitative susceptibility mapping technique applied to 120 glioma patients revealed distinct magnetic susceptibility profiles across tumor subregions, with...
Data-Driven Gating Boosts PSMA PET Quantification of Prostate Cancer Metastases
A retrospective study reports that hardware-free data-driven gating significantly increased SUV measurements, improved contrast-to-noise ratio and reduced image noise compared...
TGF-β Suppresses Glycolytic Enzyme PFKM, Fueling Metabolic Shift and EMT in Lung Cancer
A new study shows that TGF-β-driven PFKM downregulation reroutes glucose toward glycogen storage and promotes invasive, mesenchymal-like behavior in lung...
PLPP4 marks a fibroblast subset that fuels tumor growth through excess matrix deposition
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via...
Rare eye lymphoma case shows limits of local therapy in NK/T-cell disease
A published case report describes a woman whose EBV-positive NK/T-cell lymphoma relapsed inside her eye and later involved her optic...
Two Genes Flagged as Candidate Signatures of Chemoradiotherapy Exposure in Rectal Cancer
A small transcriptomic study combining five machine learning algorithms identifies NUDT6 and LINGO1 as exploratory candidate genes associated with neoadjuvant...
Neural network reads cancer’s mutational fingerprints from tiny data scraps
A supervised neural network called SuRe outperforms established methods at inferring mutational signature exposures from sparse cancer sequencing data, including...
Deep learning matches expert radiologists at outlining rectal tumors on MRI
A multicenter study of 603 rectal cancer patients found that a deep learning network segmented rectal tumors on MRI with...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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