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USC Secures $10.8 Million Grant for Clinical Trial Aiming to Enhance Hip Fracture Recovery

February 4, 2025
in Medicine
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The University of Southern California (USC) has recently been granted a significant research funding allocation of $10.8 million from the Patient-Centered Outcomes Research Institute (PCORI). This funding is dedicated to an ambitious clinical trial designed to evaluate different surgical approaches for older adults suffering from hip fractures, specifically femoral neck fractures. The trial, dubbed the “FASTER-Hip” trial, is spearheaded by Dr. Joseph Patterson, an esteemed orthopaedic surgeon at Keck Medicine of USC. His expertise in fracture care positions this study to address a critical gap in medical knowledge regarding the optimal treatment protocol for this vulnerable patient population.

Hip fractures are a major health concern, especially for older adults, with over five million individuals worldwide affected each year. These injuries can lead to severe complications, including prolonged hospitalization, decreased mobility, and even mortality. Femoral neck fractures, a common type of hip fracture, occur at the neck of the femur—an area crucial for weight-bearing during mobility. Among these fractures, a noteworthy proportion are classified as minimally displaced, where the fracture fragments remain closely aligned or only slightly separated, raising the question of the best surgical intervention.

Traditionally, surgeons have preferred internal fixation, a relatively less invasive procedure employing metal screws and plates to stabilize the fractured bone. This method has been favored for its shorter operative time and lower risk profile concerning complications like dislocation and infection. However, data have surfaced suggesting that internal fixation might not be the definitive solution, with approximately 14% of patients requiring additional surgeries, often escalating to hip replacements, within a few months post-initial intervention.

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The fundamental purpose of the FASTER-Hip trial is to provide robust evidence regarding whether initial treatment via hip replacement could offer superior outcomes compared to internal fixation for these specific fractures. While Patterson acknowledges that a hip replacement is a more extensive procedure involving increased operating time and potential blood loss, he emphasizes the need for empirical data to guide clinical decisions. The discourse among surgeons indicates a divided stance on the two approaches, necessitating a clearer understanding through this research.

Patterson, representing a collaborative alliance with key researchers—including co-principal investigators Dr. Gerard Slobogean from the University of Maryland and Dr. Sheila Sprague from McMaster University—will oversee the trial’s implementation. The trial plans to recruit 600 patients aged 60 and above across 32 clinical sites spanning the United States, Canada, and Europe. This extensive geographic participation is pivotal in ensuring a diverse sample representative of the older adult population facing hip fractures.

A distinguishing characteristic of the FASTER-Hip trial is its commitment to prioritizing patient input throughout the research. Unlike conventional trials that often focus solely on clinical results of interest to healthcare professionals, this study involves direct collaboration with patients, caregivers, geriatric specialists, and rehabilitation experts. Regular meetings will be convened to ensure that the outcomes measured during the trial reflect what is genuinely valued by the patients themselves, creating a holistic assessment of surgical effectiveness.

Patient-centered research is integral to PCORI’s mission, which aims to enhance the decision-making capabilities of patients and their families. The engagement of patients in the development of study parameters is crucial, as it steers the focus toward outcomes like independence, functional recovery, and quality of life—factors that may not always be prioritized within the confines of clinical efficacy alone.

Surgeons are trained to think critically about the factors influencing surgery success; however, insights gleaned from interacting with patients have the potential to reshape the research agenda significantly. Preliminary discussions have revealed that patients place immense value on their ability to return home post-surgery, regain mobility, and maintain independence, which may conflict with the professional focus traditionally directed towards survival rates and management of postoperative complications.

The implications of the FASTER-Hip trial extend beyond academic inquiry; the findings are set to influence clinical practice guidelines that govern decision-making in surgical interventions. Renowned organizations like the Orthopaedic Trauma Association and the American Academy of Orthopaedic Surgeons have already expressed their endorsement of this patient-centered research, recognizing its potential to revolutionize how surgeons approach hip fracture management.

Ultimately, the goal is to produce rigorous evidence that equips surgeons worldwide with the information necessary to engage in meaningful discussions with patients and families. This evidence can guide the selection of surgical approaches tailored to individual patient preferences and clinical circumstances, a crucial stepping stone in promoting personalized medical care.

This noteworthy research endeavor has been provisionally approved, pending completion of PCORI’s business and programmatic evaluations and the formal issuance of a grant contract. As the FASTER-Hip trial unfolds, it promises to illuminate critical aspects of hip fracture management for older adults—a demographic that is often overlooked in clinical research but profoundly affected by the challenges associated with these injuries.

In conclusion, the USC-led FASTER-Hip trial represents a vital undertaking in the realm of orthopaedic surgery, poised to redefine treatment protocols for older adults with hip fractures. By weaving together the perspectives of healthcare providers and patient stakeholders, the trial aspires to catalyze a transformation in how surgical options are considered and implemented in real-world clinical settings, ultimately placing patient needs at the forefront of surgical decision-making.

Subject of Research: Surgical approaches for hip fractures in older adults
Article Title: USC Launches Groundbreaking Trial to Improve Hip Fracture Treatment in Older Adults
News Publication Date: October 2023
Web References: PCORI website
References: Not provided
Image Credits: Not provided

Keywords: Hip fracture, orthopaedics, clinical trial, patient-centered research, surgical procedures, aging population, femoral neck fracture, internal fixation, hip replacement.

Tags: clinical trial evaluation in orthopaedicsDr. Joseph Patterson orthopaedic studyelderly hip fracture complicationsfemoral neck fracture treatmenthip fracture management in older adultship fracture recovery researchKeck Medicine USC researchminimally displaced femoral neck fracturesoptimal treatment protocols for hip fracturesPatient-Centered Outcomes Research Institute grantsurgical approaches for hip fracturesUSC clinical trial funding
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