Tiny Vesicles, Big Problem: How Exosomes Drive Cancer Immunotherapy Resistance
A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...
Tag: T cell exhaustion
Why Immunotherapy Fails in Gastric Cancer: Tumors, Gut Microbes and the Resistance Puzzle
A new review in Medical Oncology maps how the tumor microenvironment and gut microbiome drive resistance to immune checkpoint inhibitors ...
Scientists Uncover Why Esophageal Cancer Shrugs Off PD-1 Blockade
A new study shows that the protein SIRPĪ±, produced by esophageal cancer cells themselves, fuels both tumor growth and T-cell ...
Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...
HIV Blinds the Immune System to Lung Cancer Mutations, Study Suggests
A new analysis suggests HIV impairs the immune system's ability to recognize tumor neoantigens in non-small cell lung cancer without ...
Metabolic Weak Point Found in Exhausted Immune Cells in Head and Neck Cancer
Johns Hopkins researchers measured the metabolism of immune cells inside human head and neck tumors and found that exhausted T ...
How Tumor Mitochondria Help Cancer Hide From the Immune System
A new review in the Journal of Translational Medicine details how mitochondrial metabolic reprogramming in tumor cells drives immune evasion ...
Scientists Uncover Why a Key Antitumor T Cell Loses Its Fight in Ovarian Cancer
A new study links CEACAM1 expression and dysregulated SHP-1, LCK, and ZAP70 signaling to the functional exhaustion of follicular cytotoxic ...
Engineered CAR-T Cells That Make Their Own IL-2 Show Stronger Staying Power Against Pancreatic Cancer
A preclinical study shows that CAR-T cells engineered to secrete an Fc-fused IL-2(C125S) variant persist longer, retain mitochondrial fitness, and ...
BK Virus Kidney Infection Shows Broad Immune Disruption in Transplant Patients
A combined transcriptomic and histological study of kidney biopsy tissue reveals widespread immune activation, checkpoint upregulation, and altered T-cell dynamics ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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