Master Gene Switches in the Brain Emerge as New Drug Targets for Psychiatric Disease
A new review in Translational Psychiatry identifies the TCF/LEF transcription factor family as central nuclear effectors of Wnt/β-catenin signaling and ...
Tag: schizophrenia
Thalamus Brain Maps Reveal Two Distinct Schizophrenia Biotypes
A multisite fMRI study used individualized pulvinar-cortical connectivity deviations to identify two negative-symptom-anchored biotypes of schizophrenia.
Injectable or Pill? Year-Long Study Finds Family Caregiver Burden Falls Equally in Schizophrenia
A 48-week Chinese cohort study found that long-acting injectable antipsychotics offered no clinically meaningful advantage over oral medications in reducing ...
Antipsychotic Switch Reverses Dangerous Metabolic Syndrome in Schizophrenia Patients
A six-month prospective study found that switching stable schizophrenia patients from olanzapine to aripiprazole reversed a high-risk metabolic syndrome subtype ...
Blurred Boundaries: New Framework Links Self-Other Confusion to Empathy Problems in Schizophrenia
A new review in Translational Psychiatry proposes that empathy difficulties in schizophrenia arise from unstable regulation of the boundary between ...
Awake Alpha Bursts Reveal the Thalamus’s Hidden Working State
A biophysically constrained computational model of a lateral geniculate thalamocortical neuron reveals five distinct firing regimes and shows that the ...
Frailty Strikes More Than Half of Aging Schizophrenia Patients in Taiwanese Psychiatric Nursing Home
A cross-sectional study of 155 residents in a Taiwanese psychiatric nursing home found that 55.5 percent of aging adults with ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Machine Learning Reads Speech to Detect Cognitive Impairment in Schizophrenia
A machine learning analysis of Korean speech shows that reduced lexical richness, syntactic complexity, semantic coherence, and sentiment polarity distinguish ...
Gene Variant MCTP2 Tied to Better Recovery of Negative Symptoms in Schizophrenia
A genome-wide association study in Han Chinese patients links a variant in the synaptic gene MCTP2 to greater improvement of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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