Interleukin-2 emerges as both engine and saboteur in tumor-infiltrating lymphocyte therapy
A new review details how interleukin-2 both powers and undermines tumor-infiltrating lymphocyte therapy, and how engineered alternatives may finally break ...
Tag: melanoma
Gut Bacteria Sugar Turns Itself Into a Cancer Vaccine Supercharger
Scientists have transformed a sugar molecule produced by gut bacteria into a self-assembling nanovaccine that dramatically boosts antitumor immunity and ...
Engineered Herpes Viruses Show Modest but Meaningful Gains Against Solid Tumors
A meta-analysis of 38 clinical trials finds oncolytic herpes simplex virus therapy delivers modest anti-tumor activity across solid tumors, with ...
New Bispecific Antibody Redirects T Cells to Attack Melanoma Cells
Researchers at University Hospital Tübingen have engineered NG2-targeting bispecific antibodies that redirect T cells to kill melanoma cells, with a ...
Small Starting Margins in Mohs Surgery for Early Melanoma Do Not Raise Death Risk, Study Finds
A Mayo Clinic review of 326 early-stage melanoma patients treated with Mohs micrographic surgery found that the width of the ...
Engineered T Cell Receptors With Built-In ICOS Deliver Long-Lasting Anti-Tumor Power
Researchers have engineered T cell receptors fused to the co-stimulatory molecule ICOS, producing T cells that persist longer, resist exhaustion ...
Scientists Block a Survival Switch That Lets Melanoma Cells Spread
Australian researchers have shown that blocking the BRN2 transcription factor reverses anoikis resistance in melanoma cells and sensitizes them to ...
Early-Onset Cancers Are Rising Across the Nordic Countries, Landmark 20-Year Study Finds
A comprehensive analysis of Nordic cancer registry data from 2003 to 2022 shows incidence rates rising for 12 of 18 ...
T Cells Can Wipe Out Tumors Without Ever Recognizing Them
New research shows that activating bystander T cells inside tumors triggers antigen-independent tumor killing through cytokines, nitric oxide and innate ...
Britons Back AI Tools to Help GPs Spot Skin Cancer, Nationwide Survey Finds
A UK-wide discrete choice experiment reveals that the public supports AI-assisted skin cancer detection in general practice when clinicians remain ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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