Gut Microbe and Its Fatty Acid Break the Inflammatory Loop That Drives Obesity
A cross-species study shows that the gut bacterium Clostridium butyricum and its metabolite butyrate alleviate obesity by disrupting an LPS-EGR1 ...
Tag: macrophage polarization
Ginseng Compound Rb1 Starves Pancreatic Tumors by Turning Off Their Macrophage Allies
A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...
Lactate Fuels a Hidden Molecular Chain That Helps Liver Cancer Evade Immunity
A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...
Sugar-Coated Selenium Nanoparticles Rewire Inflamed Joint Cells to Fight Osteoarthritis
Mannose-modified selenium nanoparticles target GLUT1-high inflammatory synovial cells in osteoarthritis, restoring selenoprotein antioxidant defenses, suppressing glycolysis, and easing pain and ...
Bile Acid Sensor FXR Drives Liver Regeneration by Rebuilding Its Immune Cell Army
New research shows that the bile acid receptor FXR coordinates monocyte recruitment and Kupffer cell proliferation through CCR2 and CSF1/PI3K/Akt ...
Biomaterials That Talk to the Immune System Are Reshaping Immunotherapy
A new review maps how inorganic nanoparticles, polymers, DNA nanostructures, and cell-derived vesicles are being engineered to actively reprogram the ...
Smart Hydrogel Eye Drops Fight Dry Eye by Sensing Inflammation and Sticking to the Cornea
Researchers have developed a thermosensitive, ROS-responsive, mucoadhesive hydrogel eye drop that releases the immunosuppressant mizoribine under oxidative stress and outperforms ...
Omega-3-derived lipid Resolvin E1 rejuvenates aged muscle healing by resolving inflammation
New research in GeroScience shows that the omega-3-derived lipid mediator Resolvin E1 accelerates inflammation resolution and boosts muscle stem cell ...
Common Antibiotic Calms Children’s Wheezing by Rewriting Inflammatory Memory in Lung Immune Cells
A new study shows azithromycin eases post-inflammatory wheezing in children by inhibiting SETD1B-driven H3K4me3 methylation and rebalancing macrophage polarization in ...
Chemical Tag on mRNA Emerges as Master Switch Behind Tumor Immune Evasion
A new review in the Journal of Translational Medicine details how the m6A RNA modification acts as a bidirectional switch ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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