Why aging immune systems turn against the body: a two-step model of B cell autoreactivity
A new GeroScience review proposes that B cell-intrinsic aging relaxes immune tolerance while chronic inflammaging selectively expands autoreactive B cell ...
Tag: Inflammaging
Mitochondrial DNA Mosaics May Serve as a Molecular Clock of Human Aging
A new review argues that clonally expanded mitochondrial DNA mutations accumulate in a tissue-specific, biphasic pattern that can be read ...
RNA Methylation Enzyme METTL3 Shields the Aging Ear from Inflammatory Damage
New research shows that the RNA methyltransferase METTL3 protects against age-related hearing loss by stabilizing NFKBIA mRNA through m6A modification ...
How Inflammaging Drives Heart Attacks in Older Adults—and Immunotherapy Hopes
A new review in Biogerontology links age-related chronic inflammation, cytokine dysregulation and cellular senescence to heightened heart attack risk in ...
Midlife Obesity May Quietly Disarm the Body’s Natural Killer Cells
New research in Aging Cell shows that natural killer cell numbers, maturation, and antitumor function decline during midlife obesity, particularly ...
Cytotoxic CD4+ T cells drive aging-related myelopoiesis through CCL5–CCR5 signaling
A new Nature Aging study shows that cytotoxic CD4+ T cells accumulating in aged bone marrow drive myeloid-biased blood production ...
Berberine Emerges as a Candidate Multi-Target Modulator of Immune Aging
A new review in Biogerontology critically evaluates berberine and its derivatives as multi-target candidates for modulating immunosenescence, the age-related decline ...
How Chronic Stress May Accelerate Metabolic Ageing in Older Adults During Prolonged Crises
A Biogerontology Perspective argues that prolonged crises such as the war in Ukraine may biologically accelerate metabolic ageing in older ...
Senescent Kidney Cells Build Inflammatory Niches That Senolytics Can Dissolve
Researchers have mapped how senescent kidney cells attract immune cells into localized inflammatory niches and shown that senolytic treatments can ...
Metabolism Holds the Key to the Senescence Secretome
A Cell Research perspective argues that cellular metabolism acts as the licensing mechanism that determines the composition and intensity of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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