Experimental Drug Tolinapant Boosts Immunotherapy Response in Advanced Solid Tumors
A phase I trial found that the IAP antagonist tolinapant combined with pembrolizumab was well tolerated and produced a 33 ...
Tag: immunogenic cell death
Iron and Copper Cell Death Pathways May Hold Key to Beating Immunotherapy Resistance
A new review in Medical Oncology argues that simultaneously inducing the iron-driven cell death ferroptosis and the copper-driven cuproptosis, tuned ...
Cancer Cell Camouflage: MnO2 Nanosheets Cloaked in Tumor Membranes Supercharge Radio-Immunotherapy
Researchers have built a cancer-cell-membrane-coated manganese dioxide nanosheet that delivers the immune adjuvant R848 directly to tumors, relieving hypoxia and ...
Electric Pulses Beat Heat and Cold at Turning Dead Tumor Cells Into Cancer Vaccines
A controlled in vitro study shows irreversible electroporation induces stronger dendritic cell activation and T cell proliferation than cryoablation or ...
mRNA Vaccine Paired With Radiotherapy Shrinks HER2-Positive Lung Tumors in Mice
A HER2-targeted mRNA lipid nanoparticle vaccine combined with fractionated radiotherapy suppressed tumor growth and reprogrammed the immune microenvironment in a ...
Antibody–Drug Conjugates Emerge as Immune Modulators, Not Just Targeted Chemotherapy
A new review argues that antibody–drug conjugates act as immune modulators through immunogenic cell death, Fc-mediated effector functions and tumour ...
Viruses That Board CAR Cells: A Modular Push Against Solid Tumors
A new review proposes co-designing oncolytic viruses and CAR-T or CAR-NK cells as a modular, self-amplifying therapeutic system to overcome ...
Electron-Pumping Photosensitizer and Nanozyme Team Up to Kill Breast Cancer Cells Three Ways at Once
Researchers engineered a cyanine photosensitizer with a benzophenone electron-pumping group and loaded it into a pH-responsive, hyaluronic acid-coated iron nanozyme ...
Chemotherapy Found to Supercharge Cancer Vaccines When Timed Just Right
Researchers at Ludwig Oxford have discovered that chemotherapy regimens such as CarboTaxol can act as adjuvants that dramatically boost cancer ...
Antibody-Drug Conjugate RC48 Ignites Ferroptosis to Rally Immune Cells Against HER2 Breast Cancer
New research shows the anti-HER2 antibody-drug conjugate disitamab vedotin kills breast cancer cells through ferroptosis, releasing danger signals that activate ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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