Rock Inhibitor Y-27632 Partially Shields Mouse Testes from Chemotherapy Damage
A ROCK inhibitor partially preserved seminiferous tubule structure and reduced apoptosis in busulfan-treated mice, though sperm parameters remained below control ...
Tag: chemotherapy
Semaglutide May Boost or Block Chemotherapy Depending on the Drug Pairing
A combined genetic, cellular, and mouse study finds that semaglutide strengthens gemcitabine's antitumor effect by suppressing RRM1 while weakening methotrexate ...
Research report: PF chemotherapy combined with a PD-1/CTLA-4 bispecific antibody as first-line treatment in patients with recurrent/metastatic head and neck squamous cell carcinoma: a prospective, single-arm, phase II clinical study
A small, single-arm phase II study found a 56.3% response rate with first-line cadonilimab plus PF chemotherapy in 16 patients ...
Most treated GI cancer patients used emergency care in retrospective cohort
A retrospective cohort of 2,278 chemotherapy-treated gastrointestinal cancer patients found that 88.1% visited an emergency department and 86.5% were admitted ...
Single-arm trial reports orelabrutinib response in high-risk lymphoma
In a prospective, multicenter, single-arm phase II trial conducted at four centers in China, orelabrutinib plus R-CDOP was associated with ...
FAERS analysis maps early, diverse ifosfamide neurological adverse events
A FAERS analysis of 786 ifosfamide-related neurological reports found a strong encephalopathy signal, a median onset of two days and ...
Probiotic trial tests gut support during ovarian cancer chemotherapy
A 124-patient randomized trial will test whether probiotics reduce side effects and affect outcomes in advanced or recurrent ovarian cancer, ...
Post-treatment serum IL-6 independently associated with progression in observational cohort of advanced NSCLC with COPD
In a two-center observational cohort of 120 patients with advanced NSCLC and COPD, higher serum IL-6 measured after six treatment ...
Retrospective cohort links immune checkpoint inhibitor–containing chemoimmunotherapy to longer overall survival in recurrent nasopharyngeal carcinoma
A 37-patient retrospective cohort found that immune checkpoint inhibitor–containing chemoimmunotherapy was associated with longer overall survival than chemotherapy alone in ...
Longitudinal cohort links chemotherapy cycles with shifting liver, kidney and electrolyte markers in 60 Kenyan cervical cancer patients
A longitudinal cohort study of 60 patients at a Western Kenyan referral hospital found earlier changes in kidney-function markers and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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